Protein Alignment Cyp4d2 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 163/498 - (32%)
• Similarity: 270/498 - (54%)
• Gaps: 23/498 - (4%)

  Fly     7 VLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRLYRV 71
            :|||:..|..|.....|..:.....|.|......|::   :.|..:|.:..::|....:......
Human    27 LLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHI---QELQQDQELQRIQKWVETFPSACPH 88

  Fly    72 WIL-HQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHF 135
            |:. .::.|...|| |...|:..:.....:..|:.|..|:|.|||:..|:.|...|:::||.||:
Human    89 WLWGGKVRVQLYDP-DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHY 152

  Fly   136 KILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN-LPY 199
            .||:.:|.:......||:::.:......:|:.:|..:.|..||.|.:.|...:.:.|.:.| ..|
Human   153 DILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSY 217

  Fly   200 VQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKE 264
            :||::|:.|::..|..:|:.:.|.|:.||  :..:...:|.::.|..|:.:|:.|:..|
Human   218 IQAISDLNNLVFSRVRNAFHQNDTIYSLT--SAGRWTHRACQLAHQHTDQVIQLRKAQL------ 274

  Fly   265 TTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEIS 328
             ..|.|:..:.:||.:..||:||.:.:: |:.|||:|:|.|||||||||||||.|.||:.||.::
Human   275 -QKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALA 338

  Fly   329 RHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEI-R 392
            .||:.|:|.::||..:||:.  :.:|...|.::.:....|||:|||:||||.|||..:..|.. .
Human   339 THPKHQERCREEIHSLLGDG--ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPD 401

  Fly   393 GKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAML 457
            |:.:|.|....:.|:.|..:|:.:.:|:.|.|.||.....| |.:|::|||.|.|||||::|||.
Human   402 GRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQ-HSHAFLPFSGGSRNCIGKQFAMN 465

  Fly   458 EMKSTVSKLLRHFELLPLGPE--PRHSMNIVLRSANGVHLGLK 498
            |:|...:..|..||||| .|.  |.....:||:|.||:||.|:
Human   466 ELKVATALTLLRFELLP-DPTRIPIPIARLVLKSKNGIHLRLR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	148/434 (34%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	150/444 (34%)