Protein Alignment Cyp4d2 and CYP3A4

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 145/481 - (30%)
• Similarity: 251/481 - (52%)
• Gaps: 41/481 - (8%)

  Fly     9 LLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRL 68
            ||:|.:.:||  :|:....:|:     :|||.|||||||:|.|.    :....|..:..:|||::
Human    13 LLLAVSLVLL--YLYGTHSHGLFKKLGIPGPTPLPFLGNILSYH----KGFCMFDMECHKKYGKV 71

  Fly    69 YRVWILHQLAVFSTDPRDIEFVLSSQQH--ITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131
            :..:...|..:..|||..|:.||..:.:  .|....:..:. ::...:.::...:|...|.:::|
Human    72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG-FMKSAISIAEDEEWKRLRSLLSP 135

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN 196
            ||....|::.|.|..|...|:|..|:..|:...|:.:..|....::|:|..|:.|..|::..||.
Human   136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200

  Fly   197 LPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMH--DFTENIIRERRETLV 259
            .|:|:   :...:|...|:..:.....:|....|        .::|::  .|...:....|:: |
Human   201 DPFVE---NTKKLLRFDFLDPFFLSITVFPFLIP--------ILEVLNICVFPREVTNFLRKS-V 253

  Fly   260 NNSKETTPEEEVNFLGQKRRMALLDVLLQS-----TIDGAPLSDEDIREEVDTFMFEGHDTTTSA 319
            ...||:..|:.     ||.|:..|.:::.|     |.....|||.::..:...|:|.|::||:|.
Human   254 KRMKESRLEDT-----QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313

  Fly   320 ISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRW 384
            :||.:||::.||:|||:||:||..||  ..|:|.|...:.::::::.|:.|:|||.|....:.|.
Human   314 LSFIMYELATHPDVQQKLQEEIDAVL--PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERV 376

  Fly   385 FAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYAYIPFSAGPRN 448
            ..:||||.|..||.|....:..:.|.|||:|:..|::|.||||. .:...|.||.|.||.:||||
Human   377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

  Fly   449 CIGQKFAMLEMKSTVSKLLRHFELLP 474
            |||.:||::.||..:.::|::|...|
Human   442 CIGMRFALMNMKLALIRVLQNFSFKP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	123/419 (29%)
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	125/421 (30%)