DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp4d2 and CYP3A4

DIOPT Version :9

Sequence 1:NP_001284806.1 Gene:Cyp4d2 / 31192 FlyBaseID:FBgn0011576 Length:501 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:481 Identity:145/481 - (30%)
Similarity:251/481 - (52%) Gaps:41/481 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRL 68
            ||:|.:.:||  :|:....:|:     :|||.|||||||:|.|.    :....|..:..:|||::
Human    13 LLLAVSLVLL--YLYGTHSHGLFKKLGIPGPTPLPFLGNILSYH----KGFCMFDMECHKKYGKV 71

  Fly    69 YRVWILHQLAVFSTDPRDIEFVLSSQQH--ITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131
            :..:...|..:..|||..|:.||..:.:  .|....:..:. ::...:.::...:|...|.:::|
Human    72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG-FMKSAISIAEDEEWKRLRSLLSP 135

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN 196
            ||....|::.|.|..|...|:|..|:..|:...|:.:..|....::|:|..|:.|..|::..||.
Human   136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200

  Fly   197 LPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMH--DFTENIIRERRETLV 259
            .|:|:   :...:|...|:..:.....:|....|        .::|::  .|...:....|:: |
Human   201 DPFVE---NTKKLLRFDFLDPFFLSITVFPFLIP--------ILEVLNICVFPREVTNFLRKS-V 253

  Fly   260 NNSKETTPEEEVNFLGQKRRMALLDVLLQS-----TIDGAPLSDEDIREEVDTFMFEGHDTTTSA 319
            ...||:..|:.     ||.|:..|.:::.|     |.....|||.::..:...|:|.|::||:|.
Human   254 KRMKESRLEDT-----QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313

  Fly   320 ISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRW 384
            :||.:||::.||:|||:||:||..||  ..|:|.|...:.::::::.|:.|:|||.|....:.|.
Human   314 LSFIMYELATHPDVQQKLQEEIDAVL--PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERV 376

  Fly   385 FAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYAYIPFSAGPRN 448
            ..:||||.|..||.|....:..:.|.|||:|:..|::|.||||. .:...|.||.|.||.:||||
Human   377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441

  Fly   449 CIGQKFAMLEMKSTVSKLLRHFELLP 474
            |||.:||::.||..:.::|::|...|
Human   442 CIGMRFALMNMKLALIRVLQNFSFKP 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp4d2NP_001284806.1 p450 32..495 CDD:278495 138/453 (30%)
CYP3A4NP_059488.2 p450 39..493 CDD:365848 138/453 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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