Protein Alignment Cyp4d2 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 149/491 - (30%)
• Similarity: 253/491 - (51%)
• Gaps: 61/491 - (12%)

  Fly     9 LLVAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRL 68
            ||:|.:.:||  :|:..|.:|:     :|||.|||||||.|.:|    :....|..:..:||.::
Human    13 LLLAVSLILL--YLYGTRTHGLFKKLGIPGPTPLPFLGNALSFR----KGYWTFDMECYKKYRKV 71

  Fly    69 YRVWILHQLAVFSTDPRDIEFVLSSQQH--ITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131
            :.::...|..:..|||..|:.||..:.:  .|....:..:. ::.:.:.::...:|...|.:::|
Human    72 WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVG-FMKNAISIAEDEEWKRIRSLLSP 135

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN 196
            ||....|::.|.|..|...|:|..|:..|:...|:.:..|....::|:|..|:.|..|::..||.
Human   136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQ 200

  Fly   197 LPYVQAVND----------VTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENI- 250
            .|:|:....          |.:|.:..|:..      |......|...|     ||:...|:::
Human   201 DPFVENTKKLLRFNPLDPFVLSIKVFPFLTP------ILEALNITVFPR-----KVISFLTKSVK 254

  Fly   251 -IRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLL--QSTIDG---APLSDEDIREEVDTFM 309
             |:|.|      .|||          ||.|:..|.:::  |::.|.   ..|||.::..:...|:
Human   255 QIKEGR------LKET----------QKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303

  Fly   310 FEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRL 374
            |.|::||:|.:||.:||::.||:|||::|:||..||  ..|:|.|...:.:|::::.|:.|:|||
Human   304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL--PNKAPPTYDTVLQLEYLDMVVNETLRL 366

  Fly   375 HPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD-ADVPQIHPYA 438
            .|....:.|...:||||.|..||.|....:..:||..||:|:..|::|.||||. .:...|.||.
Human   367 FPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYI 431

  Fly   439 YIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP 474
            |.||.:|||||||.:||::.||..:.::|::|...|
Human   432 YTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	126/429 (29%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	128/431 (30%)