DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	428	Identity:	156/428 - (36%)
Similarity:	246/428 - (57%)	Gaps:	21/428 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITPTFHFKILEQF 141
            :.|...||..::.|| .:.....:.:|:....|:|.|||:..|:||...|:::||.||:.||:.:
Mouse    92 IRVLLYDPDYVKVVL-GRSDPKASGIYQFFAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPY 155

  Fly   142 VEIFDQQSAVMVEQLQSRADGMT-PINIFPVICLTALDIIAETAMGTKINAQKNPNLP-YVQAVN 204
            |:|......:|:::.: :.||.. |:.||..:.|..||.:.:.|...:.:.|.:.|.. |.:||.
Mouse   156 VKIMADSVNIMLDKWE-KLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLDENSKLYTKAVE 219

  Fly   205 DVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVNNSKETTPEE 269
            |:.|:...|..:|:.:.:.|:.::  ::.:....|.::.|:.|:.:|:.|:..|.|       ||
Mouse   220 DLNNLTFFRLRNAFYKYNIIYNMS--SDGRLSHHACQIAHEHTDGVIKMRKSQLQN-------EE 275

  Fly   270 EVNFLGQKRRMALLDVLLQSTI-DGAPLSDEDIREEVDTFMFEGHDTTTSAISFCLYEISRHPEV 333
            |:....:||.:..||:||.:.: |...|||||:|.|||||||||||||.|.||:..|.::.|||.
Mouse   276 ELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEH 340

  Fly   334 QQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEI-RGKHIP 397
            |||.::|::.:||:.  :.||...||::.:....|||:|||:|||..:.|..:..|.. .|:.||
Mouse   341 QQRCREEVQSILGDG--TSVTWDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIP 403

  Fly   398 AGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKST 462
            .|...|:.|:.|..:|.::.:|..|.|.||..|... |.:||:|||.|.|||||::|||.|:|..
Mouse   404 KGITATISIYGLHHNPRFWPNPKVFDPSRFAPDSSH-HSHAYLPFSGGSRNCIGKQFAMNELKVA 467

  Fly   463 VSKLLRHFELLPLGPE--PRHSMNIVLRSANGVHLGLK 498
            |:..|..||||| .|.  |.....:||:|.||:||.||
Mouse   468 VALTLLRFELLP-DPTRIPVPIARLVLKSKNGIHLCLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	152/423 (36%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	152/423 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650