Protein Alignment Cyp4d2 and Cyp4a12b

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Alignment Length: 505
• Identity: 170/505 - (33%)
• Similarity: 270/505 - (53%)
• Gaps: 40/505 - (7%)

  Fly     8 LLLVAFATLLLW-DFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFVKK-----NQRKYG 66
            |||:.|.|..|: ...|........|.| |..:|....:.:..|.:.|:..:|.     .|..:|
Mouse    27 LLLLLFKTAQLYLHRQWLLSSTQQFPSP-PSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWG 90

  Fly    67 RLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKIITP 131
            ...|:.:.        ||..::.:| .:.....:..|:.|..|:|.|||:..|:.|...|:::||
Mouse    91 SKVRIQVY--------DPDYMKLIL-GRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTP 146

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPN 196
            .||:.||:.:.||......||:::.:......:.:.||..|.|..||.|.:.|...:.:.|.:..
Mouse   147 AFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRK 211

  Fly   197 L-PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETLVN 260
            . .|:|||.|:.|:...|..:.:.:.|.|:|::  :.....:.|.::.||.|:.:|:.||..|.:
Mouse   212 YKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVS--SNGCLANSACQLAHDHTDQVIKSRRSQLQD 274

  Fly   261 NSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEGHDTTTSAISFCL 324
                   |||:..|.:|||:..||:||.:.:: |..|||:|:|.|||||||||||||.|.||:..
Mouse   275 -------EEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIF 332

  Fly   325 YEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDV 389
            |.::.:||.|||.::||:.:||:.  :.:|..||.::.:....|||:||::||||.:.|..:..|
Mouse   333 YALATNPEHQQRCRKEIQSLLGDG--ASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPV 395

  Fly   390 EI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPRNCIGQK 453
            .. .|:.:|.|.:..:..:.|..:|..:.:|:.|.|.|| |.....|.::::|||.|.|||||::
Mouse   396 TFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF-APGSSRHSHSFLPFSGGARNCIGKQ 459

  Fly   454 FAMLEMKSTVSKLLRHFELLPLG-----PEPRHSMNIVLRSANGVHLGLK 498
            |||.|:|..|:..|..|||||..     |.||    |||:|.||:||.||
Mouse   460 FAMNELKVAVALTLLRFELLPDPTRVPIPIPR----IVLKSKNGIHLHLK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	151/436 (35%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	155/457 (34%)