Protein Alignment Cyp4d2 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 528
• Identity: 156/528 - (29%)
• Similarity: 256/528 - (48%)
• Gaps: 76/528 - (14%)

  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGN-GILPG-PRPLPFLGNLLMYRGLD-------PEQIMDFVK 59
            ::|..:|:||.  |...|:.|.|.. ..:|| |||...||:|..:...|       .:..:|:.|
Mouse     7 LLGSAVLLAFG--LCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAK 69

  Fly    60 KNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGL----LMST-- 118
                |||.:.||.:.::.:|..|.|..::..|.|.::...:.:|:.|....|:.|    |:|.
Mouse    70 ----KYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECD 130

  Fly   119 -GRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAE 182
             || |:.:||::...|....|...:|.|::::..:||.|:::|||.||:::..::....:||:|:
Mouse   131 YGR-WYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAK 194

  Fly   183 TAMGTK----INAQKNPNLPYVQAVNDV-------TNILIKRFIHAWQRVDWIFRLTQPTEAKRQ 236
            .|.|.:    :.|||    |..|||..:       .|.|.|            |...:..:.:..
Mouse   195 AAFGMETSMLLGAQK----PLSQAVKVMLEGISASRNTLAK------------FMPGKRKQLREI 243

  Fly   237 DKAIKVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQ--STIDGAPLSDE 299
            .::|:::....::.::.|||.|...  |..|               .|:|.|  ...:||. .||
Mouse   244 RESIRLLRQVGKDWVQRRREALKRG--EDMP---------------ADILTQILKAEEGAQ-DDE 290

  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364
            .:.:...||...||:|:.:.::|.:.|:||.||:..|||.|:.:|:|..|.  :...|||.|:::
Mouse   291 VLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LDYEDLGRLQYL 353

  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            ..|:||||||:||.....|...|:..|.|..:|..|......:|:.|...|||.|..|.|:||..
Mouse   354 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP 418

  Fly   430 DVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSM--NIVLRSANG 492
            ..|:.. :.|.|||.|.|:||||:||.:|:|..::|||:..| ..|.|..|..:  ...|:..:.
Mouse   419 GAPKPR-FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIE-FRLVPGQRFGLQEQATLKPLDP 481

  Fly   493 VHLGLKPR 500
            |...|:||
Mouse   482 VLCTLRPR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	132/450 (29%)
Cyp46a1	NP_034140.1	CYP46A1-like	61..484	CDD:410706	136/465 (29%)