DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	532	Identity:	145/532 - (27%)
Similarity:	259/532 - (48%)	Gaps:	85/532 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLVAFATLLLWDF------LWRRRGNGILPGPRPLPFLGNLL-MYRGLDPEQIMDFVKKNQRKY 65
            |:|:|...:||:.:      |::::|   :|||:||||||.:| .|:||     ..|..:...||
Mouse    12 LVLLAIILVLLYRYGTCTHGLFKKQG---IPGPKPLPFLGTVLNYYKGL-----WKFDMECYEKY 68

  Fly    66 GRLYRVWILH--QLAVF-STDPRDIEFVLSSQQHITKNNLYKLLNCW-LGDGLLMSTGRKWHGRR 126
            |   :.|.|.  |:.:| .|||..|:.||..:......|........ :...:.::...:|...|
Mouse    69 G---KTWGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPVGIMSKSISLAKDEEWKRYR 130

  Fly   127 KIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINA 191
            .:::|||....|::...:.:|...::|:.|:..|:...|:.:..|:...::|:|..|..|..|::
Mouse   131 ALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTTFGVNIDS 195

  Fly   192 QKNPNLPYVQAVNDVTNILIKRFIHAWQRVDW---------IFRLTQPTEAKRQ-----DKAIKV 242
            ..||..|:|:....|.            |.|:         :|....|......     ..:|:.
Mouse   196 LNNPEDPFVENAKKVL------------RFDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEF 248

  Fly   243 MHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS------TIDGAPLSDEDI 301
            ...|.:.:...|.:     ||            ||.|:..:.:::::      ......||:.:|
Mouse   249 FKKFVDRMTENRLD-----SK------------QKHRVDFIYLMMEAYNKSKDKDSHKALSEIEI 296

  Fly   302 REEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMEN 366
            ..:...|:|.|::||:|.:||.:|.::.||::|::||:||.:.|  ..|:|.|...:..:::::.
Mouse   297 TAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEAL--PNKAPPTYDTVMAMEYLDM 359

  Fly   367 VIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD- 430
            |:.|:|||:|....:.|...:||||.|.:||.|:...:..:||..||:::..|:||:||||..:
Mouse   360 VLNETLRLYPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKEN 424

  Fly   431 VPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL-------LPLGPEPRHSMNIVLR 488
            ...|.||.|:||..|||||||.:||::.||..:.|:|::|..       :||    :.|..::|:
Mouse   425 KGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPL----KLSRELLLQ 485

  Fly   489 SANGVHLGLKPR 500
            ....:.|.:.||
Mouse   486 PVKPIVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	135/495 (27%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	136/497 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810