DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	535	Identity:	124/535 - (23%)
Similarity:	226/535 - (42%)	Gaps:	110/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGNLL-----MYRGLDPEQIMDFVKK 60
            :|.::|:|||:           |....:..:|||.....:|.|:     ::.|:.  ...::..|
Mouse    28 LLLIMGLLLLI-----------WNCESSSSIPGPGYCLGIGPLISHGRFLWMGIG--SACNYYNK 79

  Fly    61 NQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLG---DGLLMSTGRK- 121
               .||...||||..:..:..:....:..|:....:|::....:.|.| :|   :|::.:....
Mouse    80 ---MYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQC-IGMHENGIIFNNNPSL 140

  Fly   122 WHGRR----KIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAE 182
            |...|    |.:|.....:::|..||...|.    :::|....|....:::..::....||
Mouse   141 WRTIRPFFMKALTGPGLVRMVEVCVESIKQH----LDRLGEVTDTSGYVDVLTLMRHIMLD---- 197

  Fly   183 TAMGTKINAQKNPNLPYVQAVNDVTNIL--IKRFIHAWQ----------RVDWIFRLTQPTEAKR 235
                       ..|:.::....|.:.|:  |:.:.:|||          ::.|::|        :
Mouse   198 -----------TSNMLFLGIPLDESAIVKKIQGYFNAWQALLIKPNIFFKISWLYR--------K 243

  Fly   236 QDKAIKVMHDFTENIIRERRETLVNNSK-ETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDE 299
            .::::|.:.|....::.::|..:....| |...:...:.:..:||              ..|:.|
Mouse   244 YERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERR--------------GDLTKE 294

  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364
            ::.:.:...:....||.:..:.|.|..::.:|||:..:.:||..|:| ||  .:.:.|:..||.:
Mouse   295 NVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVG-DR--DIKIEDIQNLKVV 356

  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            ||.|.||:|..|.|.::.|...||..|.|..:..|||..:.|..:.| .|||..|:||..|.|:.
Mouse   357 ENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHR-LEYFPKPNEFTLENFEK 420

  Fly   430 DVPQIHPYAYI-PFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL----------------LPLGP 477
            :|    ||.|. ||..|||.|.|:..||:.||..:..|||.|::                |.|.|
Mouse   421 NV----PYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKNDLSLHP 481

  Fly   478 -EPRHSMNIVLRSAN 491
             |.||.:.|:....|
Mouse   482 NEDRHLVEIIFSPRN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	118/504 (23%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	116/494 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845259
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950