Protein Alignment Cyp4d2 and Cyp19a1

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_031836.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Alignment Length: 535
• Identity: 124/535 - (23%)
• Similarity: 226/535 - (42%)
• Gaps: 110/535 - (20%)

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGNLL-----MYRGLDPEQIMDFVKK 60
            :|.::|:|||:           |....:..:|||.....:|.|:     ::.|:.  ...::..|
Mouse    28 LLLIMGLLLLI-----------WNCESSSSIPGPGYCLGIGPLISHGRFLWMGIG--SACNYYNK 79

  Fly    61 NQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLG---DGLLMSTGRK- 121
               .||...||||..:..:..:....:..|:....:|::....:.|.| :|   :|::.:....
Mouse    80 ---MYGEFMRVWISGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQC-IGMHENGIIFNNNPSL 140

  Fly   122 WHGRR----KIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAE 182
            |...|    |.:|.....:::|..||...|.    :::|....|....:::..::....||
Mouse   141 WRTIRPFFMKALTGPGLVRMVEVCVESIKQH----LDRLGEVTDTSGYVDVLTLMRHIMLD---- 197

  Fly   183 TAMGTKINAQKNPNLPYVQAVNDVTNIL--IKRFIHAWQ----------RVDWIFRLTQPTEAKR 235
                       ..|:.::....|.:.|:  |:.:.:|||          ::.|::|        :
Mouse   198 -----------TSNMLFLGIPLDESAIVKKIQGYFNAWQALLIKPNIFFKISWLYR--------K 243

  Fly   236 QDKAIKVMHDFTENIIRERRETLVNNSK-ETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDE 299
            .::::|.:.|....::.::|..:....| |...:...:.:..:||              ..|:.|
Mouse   244 YERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERR--------------GDLTKE 294

  Fly   300 DIREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFM 364
            ::.:.:...:....||.:..:.|.|..::.:|||:..:.:||..|:| ||  .:.:.|:..||.:
Mouse   295 NVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVG-DR--DIKIEDIQNLKVV 356

  Fly   365 ENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDA 429
            ||.|.||:|..|.|.::.|...||..|.|..:..|||..:.|..:.| .|||..|:||..|.|:.
Mouse   357 ENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHR-LEYFPKPNEFTLENFEK 420

  Fly   430 DVPQIHPYAYI-PFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL----------------LPLGP 477
            :|    ||.|. ||..|||.|.|:..||:.||..:..|||.|::                |.|.|
Mouse   421 NV----PYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKNDLSLHP 481

  Fly   478 -EPRHSMNIVLRSAN 491
             |.||.:.|:....|
Mouse   482 NEDRHLVEIIFSPRN 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	110/465 (24%)
Cyp19a1	NP_031836.1	CYP19A1	72..485	CDD:410709	108/465 (23%)