Protein Alignment Cyp4d2 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_525043.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 176/523 - (33%)
• Similarity: 279/523 - (53%)
• Gaps: 50/523 - (9%)

  Fly    10 LVAFATLLLW--DFLWR----------------RRGNGILPGPRPLPFLGNLLMY----RGL-DP 51
            :.|.:||||:  .||:|                ||.......||....||:|.||    .|| |.
Human    21 IYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDE 85

  Fly    52 EQIMDFVKKNQRKYGRLYRVW---ILHQLAVFSTDPRDIEFVLSSQQHIT-KNNL-YKLLNCWLG 111
            ::::|       ....:..||   :|..|.:  ..|..|:.:|.:...|. |::| |..|..|||
Human    86 KKVLD-------NMHHVLLVWMGPVLPLLVL--VHPDYIKPLLGASAAIAPKDDLFYGFLKPWLG 141

  Fly   112 DGLLMSTGRKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADG-MTPINIFPVICLT 175
            ||||:|.|.||...|:::||.|||.||:.:::||:|.:.:|..:.:..|:| ...:::|..|.|.
Human   142 DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLM 206

  Fly   176 ALDIIAETAMGTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAI 240
            .||.:.:.......|.|:..: .|:.|:.:::.:.::|.......:|:|:  .:..:.:|..:|.
Human   207 TLDSLQKCVFSYNSNCQEKMS-DYISAIIELSALSVRRQYRLHHYLDFIY--YRSADGRRFRQAC 268

  Fly   241 KVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQS-TIDGAPLSDEDIREE 304
            .::|.||..:|:|||..|.....|...:.:     |.:.:..:||||.: ..||..|||||||.|
Human   269 DMVHHFTTEVIQERRRALRQQGAEAWLKAK-----QGKTLDFIDVLLLARDEDGKELSDEDIRAE 328

  Fly   305 VDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIK 369
            .|||||||||||:|.||:.|:.::::||.|::.::||::|:.......:...||.:|.|....||
Human   329 ADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIK 393

  Fly   370 ESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQ 433
            ||||.:|||.::.|...||::: .|:.||.|....:.|:....:|..:.....:.|.|||.|.||
Human   394 ESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQ 458

  Fly   434 IH-PYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFEL-LPLGPEPRHSMNIVLRSANGVHLG 496
            .. |.||:||||||||||||.|||.|::..|:..|..|.| :....:.|....::||:.||:.|.
Human   459 QRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLK 523

  Fly   497 LKP 499
            ::|
Human   524 VEP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_525043.1	CYP4	66..495	CDD:410721	153/438 (35%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	156/457 (34%)