DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	514	Identity:	185/514 - (35%)
Similarity:	291/514 - (56%)	Gaps:	31/514 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLP---FLGNLLMYRGL--DPEQIMDFVKK 60
            :|.|||...|:  |.:|.|.:.:...|..:...|:|..   |||:|    ||  ..|:.:..:.:
Human    21 LLLVVGASWLL--ARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHL----GLVTPTEEGLRVLTQ 79

  Fly    61 NQRKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNNL--YKLLNCWLGDGLLMSTGRKW 122
            ....|.:.:..|:.....:.: ..|..:..|:::...||..::  ||.|..|||||||:|.|.||
Human    80 LVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKW 144

  Fly   123 HGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRA-DGMTPINIFPVICLTALDIIAETAMG 186
            ...|:::||.|||.||:.:::||.:.:.:|..:.|..| :|.|.:::|..|.|..||.:.:....
Human   145 RHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFS 209

  Fly   187 TKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENII 251
            ...|.|:.|: .|:.|:.:::.:::||....::..|:::.|| |. .:|..:|.:::||||:.:|
Human   210 FDSNCQEKPS-EYITAIMELSALVVKRNNQFFRYKDFLYFLT-PC-GRRFHRACRLVHDFTDAVI 271

  Fly   252 RERRETLVNNSKETTPEEEVNFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFEG 312
            :|||.||.:...:       :||..|.:...||    :||....:|..|||||||.|.|||||.|
Human   272 QERRRTLTSQGVD-------DFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGG 329

  Fly   313 HDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPP 377
            ||||.|.:|:.||.::||||.|:|.:||::::|.:.....:...||.:|.|:...:|||||||||
Human   330 HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPP 394

  Fly   378 VPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIH-PYAYI 440
            :|...|...:||.: ..:.||.|....:.||.:..:|..:..|:.:.|.|||.:..|.. |.|:|
Human   395 IPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFI 459

  Fly   441 PFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLGLKP 499
            ||||||||||||||||.|||..::..|..|.:||...|||.:..||||:.:|:.|.::|
Human   460 PFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	174/477 (36%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	169/465 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650