Protein Alignment Cyp4d2 and CYP46A1

DIOPT Version :9

• Sequence 1: NP_001284806.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 158/520 - (30%)
• Similarity: 256/520 - (49%)
• Gaps: 60/520 - (11%)

  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGN-GILPG-PRPLPFLGNLLMYRGLD-------PEQIMDFVK 59
            ::|..:|:||.  |...|:.|.|.. ..:|| |||...||:|..:...|       .:..:|:.|
Human     7 LLGSAVLLAFG--LCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAK 69

  Fly    60 KNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGD-----GLLMSTG 119
                |||.:.||.:.|:.:|..|.|..::..|.|.::...:.:|:.|....|:     ||:....
Human    70 ----KYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN 130

  Fly   120 -RKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAET 183
             .:||.:|::|...|....|...:|.|::::..:||.|:::|||.||:::..::..||:||:|:.
Human   131 YERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA 195

  Fly   184 AMGTK----INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMH 244
            |.|.:    :.|||    |..|||.     |:...|.|.:.....|...:..:.:...::|:.:.
Human   196 AFGMETSMLLGAQK----PLSQAVK-----LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251

  Fly   245 DFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQ--STIDGAPLSDEDIREEVDT 307
            ....:.::.|||.|...       |||.          .|:|.|  ...:||. .||.:.:...|
Human   252 QVGRDWVQRRREALKRG-------EEVP----------ADILTQILKAEEGAQ-DDEGLLDNFVT 298

  Fly   308 FMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESL 372
            |...||:|:.:.::|.:.|:||.||:..|||.|:.:|:|..|.  :...|||.|:::..|:||||
Human   299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY--LDFEDLGRLQYLSQVLKESL 361

  Fly   373 RLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPY 437
            ||:||.....|...|:..|.|..:|..|......:|:.|...|||.|..|.|:||....|:.. :
Human   362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-F 425

  Fly   438 AYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSM--NIVLRSANGVHLGLKPR 500
            .|.|||.|.|:||||:||.:|:|..::|||:..| ..|.|..|..:  ...|:..:.|...|:||
Human   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489

  Fly   501  500
            Human   490  489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	147/484 (30%)
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	144/466 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810