DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	523	Identity:	188/523 - (35%)
Similarity:	289/523 - (55%)	Gaps:	48/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLVA----FATLLLWDFLWRRRGNGILPGPRPLP----FLGNLLMY----RGLDPEQIMDFVK 59
            :|||:.    .|.:|...:::.|..:.:...|:| |    |||:|.|.    .||  :::.:.|
Mouse    26 LLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQP-PKWNWFLGHLGMITPTEHGL--KEVTNLV- 86

  Fly    60 KNQRKYGRLYRVWILHQLAVFS-TDPRDIEFVLSSQQHITKNNL--YKLLNCWLGDGLLMSTGRK 121
               ..|.:.:..|:...:.:.: ..|..|..||::...:....:  |..|..|||||||:|.|.|
Mouse    87 ---ATYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGLLLSDGDK 148

  Fly   122 WHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRAD-GMTPINIFPVICLTALDIIAETAM 185
            |...|:::||.|||.||:.:|:||:..:.:|..:.|..|. |...:::|..|.|..||.:.:...
Mouse   149 WSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQHLASGGSARLDVFENISLMTLDSLQKCVF 213

  Fly   186 GTKINAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENI 250
            ....|.|:||: .|:.|:.:::.::.||:......:|.:::||  ...:|..||..::|.||:.:
Mouse   214 SFDSNCQENPS-EYISAILELSALVTKRYHQLLLHIDSLYQLT--CSGRRFHKACHLVHSFTDAV 275

  Fly   251 IRERRETLVNNSKETTPEEEVNFLGQKRRMALLD----VLLQSTIDGAPLSDEDIREEVDTFMFE 311
            |::||.||.:       :.|.:.|..|.:...||    :||....||..|||||||.|.||||||
Mouse   276 IQDRRRTLPS-------KHEDDVLKAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFE 333

  Fly   312 GHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKS-------PVTLR-DLGELKFMENVI 368
            |||||.|.:|:.||.::||||.|:|.:||::::| .||:|       .|.|| ||.:|.|:...|
Mouse   334 GHDTTASGLSWILYNLARHPEYQERCRQEVQELL-RDRESTEIECSCAVFLRDDLAQLPFLTMCI 397

  Fly   369 KESLRLHPPVPMIGRWFAEDVEI-RGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-V 431
            ||||||||||.:|.|...:|:.: .|:.||.|....:.||....:|..:..|:.:.|.|||.: :
Mouse   398 KESLRLHPPVTVISRRCTQDIVLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENI 462

  Fly   432 PQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSMNIVLRSANGVHLG 496
            ....|.|:|||||||||||||.|||.|||..::..|..|.:||...|||....::||:..|:.|.
Mouse   463 KDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLR 527

  Fly   497 LKP 499
            ::|
Mouse   528 VEP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	180/488 (37%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	180/486 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650