DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d2 and cyp26c1

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_031761583.1	Gene:	cyp26c1 / 100489980	XenbaseID:	XB-GENE-1219115	Length:	608	Species:	Xenopus tropicalis

Alignment Length:	581	Identity:	118/581 - (20%)
Similarity:	211/581 - (36%)	Gaps:	166/581 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLVAFATLLLWDFLW---RRRGNGI-LP-GPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGR 67
            |:|:..|:..||...|   |.||:.: || |....||.|..|.:.    .|...|....:.|||.
Frog    22 LVLLLAASHQLWSLRWHSTRDRGSSLPLPKGSMGWPFFGETLHWL----VQGSSFHSSRREKYGN 82

  Fly    68 LYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLM-STGRKWHGRRKIITP 131
            :::..:|.:..:..|...:|..:|..:.|:......:.....||...|. |.|.....:||:::.
Frog    83 IFKTHLLGKPVIRVTGAENIRKILLGEHHLVSTQWPQSTQIILGSNTLSNSIGELHRQKRKMMSK 147

  Fly   132 TFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALD--IIAETAMGTKINAQKN 194
            ......||.::....:  ||..| ::|...|:.|:::  :.|..||.  |.|...:|..:...:.
Frog   148 VLSSAALESYLPRIHE--AVRWE-VRSWCRGVGPVSM--LSCAKALTFRIAARILLGLSLTDTQF 207

  Fly   195 PNL--PYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQD-KAIKVMHDFTENIIRERRE 256
            ..|  .:.|.|.::                :...|..|....|:. ||...:|.:.|..|:|:.
Frog   208 QELTRTFEQLVENL----------------FCLPLDIPFSGLRKGMKARDTLHQYMEEAIKEKL- 255

  Fly   257 TLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGA-PLSDEDIREEVDTFMFEGHDTTTSAI 320
                :.::....|:.           ||.|:.|..:|. .::.::::|.....:|....||.||.
Frog   256 ----SKRDPDACEDA-----------LDYLINSAKEGGKEINMQELKESAIELIFAAFLTTASAS 305

  Fly   321 SFCLYEISRHPEVQQRLQQEIRD------------------------------------------ 343
            :..:..:.:||....:::||:..
Frog   306 TSLVLLLLKHPSAIHKIRQELASHGLSEHCEQCLPATENPNNNILQDNGHQCLTAGCQLPLVMGT 370

  Fly   344 --------------------------------VLGEDR--KSP---------------------- 352
                                            |.||:|  ::|
Frog   371 EGQVKTLWEQTKQLLTDRTDQDPQNSLSSKNLVNGENRIQEAPCSHDKSNCSPVPGKLQNSVFEG 435

  Fly   353 -----VTLRDLGELKFMENVIKESLRLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRD 412
                 ::|..|..|.:::.|:||.|||.|||....|...:..|:.|..||.|    ..:...:||
Frog   436 TCQQNISLEKLKSLHYLDCVVKEVLRLLPPVSGGYRTALQTFELDGYQIPKG----WSVMYSIRD 496

  Fly   413 PE----YFESPDEFRPERF--DADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLL 467
            ..    .:::.:.|.||||  :.|..::..:.||||..|.|:|||::.|.:.:|....:|:
Frog   497 THETAAVYQNAEMFDPERFSTERDEGKLGRFNYIPFGGGARSCIGKELAQIILKILAMELV 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	108/553 (20%)
cyp26c1	XP_031761583.1	cytochrome_P450	59..588	CDD:425388	104/544 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910