DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d2 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	534	Identity:	146/534 - (27%)
Similarity:	250/534 - (46%)	Gaps:	90/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VAFATLLLWDFLWRRRGNGI-----LPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQRKYGRLYR 70
            |...|.|::.:::....:|:     :|||:|||..|.:..|.    :.:..|.:...:|||:::.
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYF----DGMWKFDEDCYKKYGKIWG 73

  Fly    71 VWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNC-WLGDGLLMSTGRKWHGRRKIITPTFH 134
            .::..:..:...||..|:.||..:.:....|...|... :|...:.:|...:|...|.:::|||.
Mouse    74 FYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPVGFLKKSITISEDEEWKRLRTLLSPTFT 138

  Fly   135 FKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQKNPNLPY 199
            ...|::...|..|...::|..|:...:...|||:..:....::|:|..|:.|..|::..||..|:
Mouse   139 SGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTSFGVNIDSLNNPQNPF 203

  Fly   200 VQAVNDV-----------TNILIKRFIHAWQRVDW-IFRLTQPTEAKRQDKAIKVMHDFTENIIR 252
            ||....:           :.||.......::.::. ||    |.::         |:.|.:.:.|
Mouse   204 VQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIF----PRDS---------MNFFKKFVKR 255

  Fly   253 ERRETLVNNSKETTPEEEVNFL----------GQKRRMALLDVLLQSTIDGAPLSDEDIREEVDT 307
            .::|.|.:..|     ..|:||          ||:.:.|              |||.::..:...
Mouse   256 MKKERLASKQK-----NRVDFLQLMMNTQNSKGQESQKA--------------LSDLEMAAQAVI 301

  Fly   308 FMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESL 372
            |:|.|:|.|:::||..:||::.||:||::||.||...|  ..|:|||...|.::::::.|:.|||
Mouse   302 FIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL--PNKAPVTYDALMDMEYLDMVVNESL 364

  Fly   373 RLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDAD-VPQIHP 436
            ||:|....:.|...:||||.|..||.||...:.|:.|.|:|||:..|.||.|.||..: ...|.|
Mouse   365 RLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDP 429

  Fly   437 YAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLP---------------LGPEPRHSMNIV 486
            |.|:||..|||||:..:||::.||..|..:|::|.:.|               ..||....:.:|
Mouse   430 YIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKISREPVFQPEKPIILKVV 494

  Fly   487 LRSANGVHLGLKPR 500
            .|.        |||
Mouse   495 SRD--------KPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	139/501 (28%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	137/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810