DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3630 and ABRA

DIOPT Version :9

Sequence 1:	NP_001259177.1	Gene:	CG3630 / 31189	FlyBaseID:	FBgn0023540	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_631905.1	Gene:	ABRA / 137735	HGNCID:	30655	Length:	381	Species:	Homo sapiens

Alignment Length:	144	Identity:	64/144 - (44%)
Similarity:	89/144 - (61%)	Gaps:	5/144 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SPLSSKVAMFNNQATQHKQSQLLNPFSQD---GRAASPKPTFSKDQYGKPLAGSLTEMRGQKANI 78
            ||:.:....:...|.:|.|||.|||||::   ..|.|.:.....:.||:|..|:.|..|.::|..
Human   240 SPVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELAMSTRLHKGDEGYGRPKEGTKTAERAKRAEE 304

  Fly    79 HVMKEMLELCQIINSEGYDVKDEPTMRVIPFGELFNIYNYISDKVVGILLRARKHKLVDFEGEML 143
            |:.:||:::|.||.:.....:|....  :.||:||:.|..|||||||||:|||||.|||||||||
Human   305 HIYREMMDMCFIICTMARHRRDGKIQ--VTFGDLFDRYVRISDKVVGILMRARKHGLVDFEGEML 367

  Fly   144 YQRRDDDVPVFLLK 157
            :|.|||.|.:.|||
Human   368 WQGRDDHVVITLLK 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3630	NP_001259177.1	Costars	79..155	CDD:291377	40/75 (53%)
ABRA	NP_631905.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..207
		Actin-binding 1. /evidence=ECO:0000250	199..299		19/58 (33%)
		Interaction with actin. /evidence=ECO:0000250\|UniProtKB:Q8BUZ1	240..285		14/44 (32%)
		Actin-binding 2. /evidence=ECO:0000250	300..381		42/82 (51%)
		Costars	305..379	CDD:317149	40/75 (53%)
		Interaction with actin. /evidence=ECO:0000250\|UniProtKB:Q8BUZ1	352..381		20/28 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144476
Domainoid	1	1.000	79	1.000	Domainoid score	I8750
eggNOG	1	0.900	-	-		E1_KOG3376
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002921
OrthoInspector	1	1.000	-	-		otm40349
orthoMCL	1	0.900	-	-		OOG6_107089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3023
SonicParanoid	1	1.000	-	-		X2739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.630