Protein Alignment Cyp4d1 and ERG11

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 568
• Identity: 122/568 - (21%)
• Similarity: 223/568 - (39%)
• Gaps: 134/568 - (23%)

  Fly     7 AILASAL-FVGLLLYH---LKFKRLIDLISYMP----------------GPPV----LPLVGHGH 47
            :|:..|| :|.:.|.|   |...:.|.||..:|                .||:    :|.||...
Yeast     6 SIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAV 70

  Fly    48 HFIGKPPHEMVKKIFEFMETYSK---DQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYK 109
            .:..||        :||.|...|   |....|.||..:.|.:| ||..|.|     ||.|..:..
Yeast    71 VYGMKP--------YEFFEECQKKYGDIFSFVLLGRVMTVYLG-PKGHEFV-----FNAKLADVS 121

  Fly   110 A-------LEPWLKEGLLVS-RGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRL 166
            |       ..|...:|::.. ...:..:::|.:..|...:....:|.:..:......|:.:..||
Yeast   122 AEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRL 186

  Fly   167 KHGDSGFSLYDWINLCTMD-----------TICETAMGVSINAQSNADSEYVQAVKTISMVLHKR 220
            ....:|          |:|           |...:.:|..:.|:.:.|..|          |:..
Yeast   187 NERTTG----------TIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAY----------LYSD 231

  Fly   221 MFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSND--DADVGAKR 283
            :.......:..:...||....|:      ...:|.|......||:|   :..:||  |.|:
Yeast   232 LDKGFTPINFVFPNLPLEHYRKR------DHAQKAISGTYMSLIKE---RRKNNDIQDRDL---- 283

  Fly   284 KMAFLDILLQSTV--DERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEI 346
                :|.|::::.  |...:::.:|...:...:..|..|:::...:...::|..|:.|::.:||.
Yeast   284 ----IDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQ 344

  Fly   347 RSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEI--NGKLIPAGTNIGI 409
            ..|:...|. .::|:||.::..::..:||||||:..:..|.|||::|..:  ...:||||.::.:
Yeast   345 MRVLDGGKK-ELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLV 408

  Fly   410 SPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYA-------------------YIPFSAGPRN 455
            ||.|...|:|.|...:.|...|::    .:..:.|:                   |:||..|...
Yeast   409 SPGYTHLRDEYFPNAHQFNIHRWN----KDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHR 469

  Fly   456 CIGQKFAMLEIKAIVANVLR----HYEVDFVGDSSEPPVLIAELILRT 499
            |||:.||..::..:::..:|    ||.   .|.:..||...:.:.|.|
Yeast   470 CIGEHFAYCQLGVLMSIFIRTLKWHYP---EGKTVPPPDFTSMVTLPT 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	99/475 (21%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	101/483 (21%)