Protein Alignment Cyp4d1 and CYP4F2

DIOPT Version :9

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 176/517 - (34%)
• Similarity: 286/517 - (55%)
• Gaps: 31/517 - (5%)

  Fly     1 MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFM 65
            :.|::|   ||.|...:|.:...|......:...|.||..... .||..:..|..|.::.:.:.:
Human    21 LLLLVG---ASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWF-WGHQGMVNPTEEGMRVLTQLV 81

  Fly    66 ETYSKDQVLKVWLGPELNVL-MGNPKDVEVVL---GTLRFNDKAGEYKALEPWLKEGLLVSRGRK 126
            .||  .|..|||:||...:| :.:|..:..|:   ..:...||. .|..|||||.:|||:|.|.|
Human    82 ATY--PQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKF-FYSFLEPWLGDGLLLSAGDK 143

  Fly   127 WHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETA 191
            |.:.|:::||||||.||..::::|.: |.:::....|.....|.:...:::.|:|.|:|::.:..
Human   144 WSRHRRMLTPAFHFNILKPYMKIFNE-SVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCV 207

  Fly   192 MGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKII 256
            .....:.|.. .|||:.|:..:|.::.||...||...|..|.|||..:..::|..::|.||:.:|
Human   208 FSFDSHCQEK-PSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVI 271

  Fly   257 VQRREELIREGSSQESSNDDADVGAKRK-MAFLDILLQS-TVDERPLSNLDIREEVDTFMFEGHD 319
            .:||..|..:|     .:|.....||.| :.|:|:||.| ..|.:.||:.|||.|.|||||||||
Human   272 QERRRTLPSQG-----VDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHD 331

  Fly   320 TTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVP 384
            ||:|.|.:..|::|.|||.|::|.:|::.::.:.:...:.::.|..|.::.:|:||:||::|.||
Human   332 TTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVP 396

  Fly   385 LLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIP 448
            ::.|.|.:|..: :|::||.|....||.........::.:|.::.|.|||.....|: :|.|:||
Human   397 VISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKER-SPLAFIP 460

  Fly   449 FSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEP---PVLIAELILRTKEPLMFKV 507
            |||||||||||.|||.|:|.::|..|..:.|  :.|.:||   |    ||:||.:..|..:|
Human   461 FSAGPRNCIGQTFAMAEMKVVLALTLLRFRV--LPDHTEPRRKP----ELVLRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	168/481 (35%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	10/38 (26%)
		p450	52..515	CDD:365848	168/480 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750