DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and CYP86B1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_197710.1	Gene:	CYP86B1 / 832383	AraportID:	AT5G23190	Length:	559	Species:	Arabidopsis thaliana

Alignment Length:	545	Identity:	139/545 - (25%)
Similarity:	240/545 - (44%)	Gaps:	88/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPP---HEMVKKIFEFME---- 66
            |..|:||.:.::.|:.|:       ..|.||.|       |:|..|   ..:...|:|::.
plant    41 LLIAIFVFVAIHALRQKK-------YQGLPVWP-------FLGMLPSLAFGLRGNIYEWLSDVLC 91

  Fly    67 ----TYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFN-DKAGEY--KALEPWLKEGLLVSRG 124
                |:   |....|.....:.:..:|::||.:|.. ||: ...|.|  ..|...|.:|:..:..
plant    92 LQNGTF---QFRGPWFSSLNSTITCDPRNVEHLLKN-RFSVFPKGSYFRDNLRDLLGDGIFNADD 152

  Fly   125 RKWHKRRKIITPAFHFKILDQFV--EVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTI 187
            ..|.::||..:..||.....|..  .:||...:.||..:|..  ....|...|.|.:...|.|.:
plant   153 ETWQRQRKTASIEFHSAKFRQLTTQSLFELVHKRLLPVLETS--VKSSSPIDLQDVLLRLTFDNV 215

  Fly   188 CETAMGVSINAQSNADSEYVQAVK-----TISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNV 247
            |..|.||.... ...|...:...|     |.:.|:...|...:::| :.|:.....:..|:::..
plant   216 CMIAFGVDPGC-LGPDQPVIPFAKAFEDATEAAVVRFVMPTCVWKF-MRYLDIGTEKKLKESIKG 278

  Fly   248 LHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLD--IREEV 310
            :..|.:::|..|::||..||.:.:.|:             |..:.....||:..|..|  :|:..
plant   279 VDDFADEVIRTRKKELSLEGETTKRSD-------------LLTVFMGLRDEKGESFSDKFLRDIC 330

  Fly   311 DTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVV------GN-DKS--TPV-SYELLNQ 365
            ..|:..|.||:|.||.:||:.:..:||.::|...|:..::      || :||  .|| ..|.:.:
plant   331 VNFILAGRDTSSVALSWFFWLLEKNPEVEEKIMVEMCKILRQRDDHGNAEKSDYEPVFGPEEIKK 395

  Fly   366 LHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNI--GISPLY----LGRREELFSEP 424
            :.|:...:.|.||:|||||:..::|.||     .:.|.||.:  |...:|    :||.|.::.:.
plant   396 MDYLQAALSEALRLYPSVPVDHKEVQED-----DVFPDGTMLKKGDKVIYAIYAMGRMEAIWGKD 455

  Fly   425 NI-FKPERF--DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFV-GDS 485
            .: |:|||:  |....:|  :.|.:..|:.|||.|:|:.||..::|:..|.::..|:|..| |..
plant   456 CLEFRPERWLRDGRFMSE--SAYKFTAFNGGPRLCLGKDFAYYQMKSTAAAIVYRYKVKVVNGHK 518

  Fly   486 SEPPVLIAELILRTKEPLMFKVRER 510
            .||.:   .|.:..|..||..:..|
plant   519 VEPKL---ALTMYMKHGLMVNLINR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	132/514 (26%)
CYP86B1	NP_197710.1	PLN03195	38..541	CDD:215627	139/545 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100859
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820