DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	522	Identity:	163/522 - (31%)
Similarity:	284/522 - (54%)	Gaps:	45/522 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFM 65
            :.|.:...||..|...:.|| |:.:||:..:|..||||...|:|| ..|:.:          :.|
Mouse    14 LHLALVFCLALVLMQAMKLY-LRRQRLLRDLSPFPGPPAHWLLGH-QKFLQE----------DNM 66

  Fly    66 ETYSKDQVLK-------VWLGP-ELNVLMGNPKDVEVVLGTLRFNDKAGEY--KALEPWLKEGLL 120
            ||.  |:::|       .|:|| :....:.:|...::.|..   .|...:|  :.|.|.:..|||
Mouse    67 ETL--DEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLSR---TDPKMQYLHQLLTPCIGRGLL 126

  Fly   121 VSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMD 185
            ...|.:|.:.|.::|||||..||...|:......:.:|...|: .....::...:::.|||.|:|
Mouse   127 NLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVMLDKWEK-MWTTQETTIEVFEHINLMTLD 190

  Fly   186 TICETAMGVSINAQSNADSE-YVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLH 249
            .|.:.|.|...|.|.|...| ||:|...:..::..|::|..:..|:.:.|:|.....::...|:|
Mouse   191 IIMKCAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIH 255

  Fly   250 QFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTV-DERPLSNLDIREEVDTF 313
            |:||||| |.|:::::....|:.:        :....||||:|.:.. |||..|:.|:|.||:||
Mouse   256 QYTEKII-QDRKKILKNQVKQDDT--------QTSQIFLDIVLSAQAEDERAFSDADLRAEVNTF 311

  Fly   314 MFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLR 378
            |:.|||.:::::.:..|.:|.:||.|.:|..||||::|:..|  :::|.|:::.|..:|:|||||
Mouse   312 MWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSS--ITWEQLDEMSYTTMCIKETLR 374

  Fly   379 MYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLN 442
            :.|.||.:.|::.:...: :|..:|||..:.:|...|.....::::|.:|.|.|| ....:::.:
Mouse   375 LIPPVPSISRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPLRF-TKENSDQRH 438

  Fly   443 PYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKV 507
            |.|::|||:||||||||:|||||:|..:|.:|.|::|  ..|.:.||...:..:||.|..:...:
Mouse   439 PCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQV--APDLTRPPAFSSHTVLRPKHGIYLHL 501

  Fly   508 RE 509
            ::
Mouse   502 KK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	153/484 (32%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	153/482 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3670
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.800