DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	527	Identity:	171/527 - (32%)
Similarity:	281/527 - (53%)	Gaps:	52/527 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFM 65
            :.||:|:.|.:.:......::...:||    ...|.||..... .||..:..|..|.:|...:..
Human    22 LLLVVGSWLLARILAWTYAFYNNCRRL----QCFPQPPKRNWF-WGHLGLITPTEEGLKNSTQMS 81

  Fly    66 ETYSKDQVLKVWLGPELN-VLMGNPKDVEVVLGT-----------LRFNDKAGEYKALEPWLKEG 118
            .|||  |...|||||.:. :::.:|..:..:...           :||         |:|||.||
Human    82 ATYS--QGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRF---------LKPWLGEG 135

  Fly   119 LLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKH----GDSGFSLYDWI 179
            :|:|.|.||.:.|:::||||||.||..::.:|.|.:     |:..|:.:|    |.|...:::.|
Human   136 ILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSA-----NIMLDKWQHLASEGSSRLDMFEHI 195

  Fly   180 NLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKA 244
            :|.|:|::.:.......:.|.. .|||:..:..:|.::.||..:||...|..|.|:...|...:|
Human   196 SLMTLDSLQKCIFSFDSHCQER-PSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRA 259

  Fly   245 LNVLHQFTEKIIVQRREELIREGSSQESSNDD--ADVGAKRKMAFLDILLQS-TVDERPLSNLDI 306
            ..::|.||:.:|.:||..|..:|.      ||  .|....:.:.|:|:||.| ..|.:.||:.||
Human   260 CRLVHDFTDAVIRERRRTLPTQGI------DDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDI 318

  Fly   307 REEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDL 371
            |.|.|||||.|||||:|.|.:..||:|.|||.|::|.:|::.::.:.....:.::.|.||.::.:
Human   319 RAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTM 383

  Fly   372 CVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVV 435
            ||||:||::|..|.:.|...:|..: :|::||.|....|..:.:.....::.:|.::.|.|||..
Human   384 CVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPE 448

  Fly   436 TTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTK 500
            .:..: :|.|:|||||||||||||.|||.|:|.::|.:|.|:.  |:.|.:||...: |||:|.:
Human   449 NSKGR-SPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR--FLPDHTEPRRKL-ELIMRAE 509

  Fly   501 EPLMFKV 507
            ..|..:|
Human   510 GGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	164/491 (33%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	161/481 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750