DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	544	Identity:	153/544 - (28%)
Similarity:	265/544 - (48%)	Gaps:	108/544 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFVGLLLY-------HLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSK 70
            |...|:|:       |..||:|     .:|||..|||:|            .:...::.|..:.:
Mouse    15 LVTSLVLFYIYGTYSHGLFKKL-----GIPGPKPLPLLG------------TIFNYYDGMWKFDE 62

  Fly    71 D---QVLKVW---LGPELNVLMGNPKDVEVVL--------GTLRFNDKAGEYKALEPWLKEGLLV 121
            |   :..|:|   .||:..:.:.:|:.:::||        ...||....|       ::|:.:.:
Mouse    63 DCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVG-------FMKKAITI 120

  Fly   122 SRGRKWHKRRKIITPAF-------HFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWI 179
            |...:|.:.|.:::|.|       .|.|:.|:.::       |:||:.::..| |:. .|:.|..
Mouse   121 SEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDI-------LVRNLRREEEK-GEP-ISMKDIF 176

  Fly   180 NLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFN------ILYRFDLTYMLTPLA 238
            ...:||.|..|:.||::::.:|....:||..|.|   |..::|:      ||:.|     |||:.
Mouse   177 GAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKI---LKFKIFDPFLLSIILFPF-----LTPIY 233

  Fly   239 RA------EKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILL----- 292
            ..      .:.::|...:|.:::   ::|.|        :||.      |.::.||.:::
Mouse   234 EMLNFSIFPRDSMNFFKKFVKRM---KKERL--------ASNQ------KNRVDFLQLMMNTQNS 281

  Fly   293 QSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTP 357
            :....::.||:|::..:...|:|.|:|.||:::....|.:||||:.|||..:||...:.|  ..|
Mouse   282 KGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPN--KAP 344

  Fly   358 VSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLY-LGRREELF 421
            |:|:.|..:.|:|:.|.|:||:||....|.|...:|.||||..||.||.:.| |:| |.|..|.:
Mouse   345 VTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMI-PIYPLHRNPEYW 408

  Fly   422 SEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSS 486
            .||..|.||||...... .::||.|:||..|||||||.:||::.||..|..||:::.|....::.
Mouse   409 PEPQEFCPERFSKENKG-NIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 472

  Fly   487 EPPVLIAELILRTKEPLMFKVRER 510
            .|..:..|.|.:.::|::.||..|
Mouse   473 IPLKISREPIFQPEKPIILKVVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	143/510 (28%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	143/510 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910