DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	181/526 - (34%)
Similarity:	284/526 - (53%)	Gaps:	53/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVIGA--ILASALFVGLLLYHLKFKRLIDLISYMPGPPVLP-LVGHGHHFIG--KPPHEMVKKIF 62
            |:.||  |||..| ..:...:..|:||    ...|.||... |:||    :|  .|..:.:|::.
  Rat    23 LLFGASWILAQIL-TQIYAAYRNFRRL----RGFPQPPKRNWLMGH----VGMVTPTEQGLKELT 78

  Fly    63 EFMETYSKDQVLKVWLGPELNVLMGNPKDV---------EVVLGTLRFNDKAGEYKALEPWLKEG 118
            ..:.||  .|...:|:||.:.|:.....|:         .|.|..:.|      |..|:|||.:|
  Rat    79 RLVGTY--PQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIF------YTILKPWLGDG 135

  Fly   119 LLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCT 183
            ||||.|.||.:.|:::||||||.||..:|::| ..|.:::....:..:..|.|...:::.::|.|
  Rat   136 LLVSAGDKWSRHRRMLTPAFHFNILKPYVKIF-NDSTNIMHAKWKRLISEGSSRLDMFEHVSLMT 199

  Fly   184 MDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVL 248
            :|::.:.......|.|..: |||:.|:..:|.::.||....|...||.|.|||......||.|::
  Rat   200 LDSLQKCVFSFDSNCQEKS-SEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACNLV 263

  Fly   249 HQFTEKIIVQRREELIREGSSQESSNDDADVGAKRK-MAFLDILLQSTVDE--RPLSNLDIREEV 310
            |:||:.:|.:||..|..:|..:...:.     ||.| :.|:|:|| .|.||  :.||:.|||.|.
  Rat   264 HEFTDAVIRERRRTLPDQGLDEFLKSK-----AKSKTLDFIDVLL-LTKDEDGKELSDEDIRAEA 322

  Fly   311 DTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKE 375
            |||||||||||:|.|.:..||:|.|||.|::|.:|::.::.:.....:.::.|.||.::.:|:||
  Rat   323 DTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKE 387

  Fly   376 TLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAE 439
            :||::|.|.::.|...:|..: :|:.||.|....||...:.....::.:|.::.|.|||.....:
  Rat   388 SLRLHPPVTVISRCCTQDILLPDGRTIPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPENIKD 452

  Fly   440 KLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEP---PVLIAELILRTKE 501
            . :|.|:|||||||||||||.|||.|:|..:|..|..:.:  :.|..||   |    |||||.:.
  Rat   453 S-SPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRL--LPDDKEPRRQP----ELILRAEG 510

  Fly   502 PLMFKV 507
            .|..:|
  Rat   511 GLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	170/490 (35%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	162/463 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750