DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	524	Identity:	207/524 - (39%)
Similarity:	304/524 - (58%)	Gaps:	30/524 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVIGAILASALFVGLLLYHLKFKRLIDLISY---------MPG-PPVLPLVGHGHHF---IGK 52
            |.::.|..:...||..:||..|.......|.:|         :|| ....|::|:...|   .|
Zfish     1 MGILFGLYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAG- 64

  Fly    53 PPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKE 117
               :...:|.|.........:.|||:||...:::.:.:::||||...|..||:..|:.|.|||..
Zfish    65 ---DFFNQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGT 126

  Fly   118 GLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLC 182
            |||.|.|.||..|||::||.|||.||..|:||..:.:..|::.|:  :|:.|:. |:.:::|.||
Zfish   127 GLLTSTGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQ--KLEDGEP-FNCFNFITLC 188

  Fly   183 TMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNV 247
            .:|.|||||||..|.|||||||||||:|..:|.::.||........|..|......:...|.|.:
Zfish   189 ALDIICETAMGKKIYAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKI 253

  Fly   248 LHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDE-RPLSNLDIREEVD 311
            ||.||..:|.:|.|.:..|..|      |:|.|.:::.||||:||::|.:. :.||:.||:||||
Zfish   254 LHSFTANVIRERAEFMSSEPDS------DSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVD 312

  Fly   312 TFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKET 376
            ||||||||||::::.:..:.|.:|||.||....|::.|.|:.: ..|..|.|.:|.|::..:||:
Zfish   313 TFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSE-RHVGVEDLKKLRYLECVIKES 376

  Fly   377 LRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKL 441
            ||::|||||..|.:.|.|.|||..:|.|.|..|.|..|.|....|.||..|:|||| :...::..
Zfish   377 LRIFPSVPLFARSICEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERF-MPENSKGR 440

  Fly   442 NPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFK 506
            :|||||||||||||||||:|||:|.|.::|.:|||::|: ...|.|....:.|||||.::.:..|
Zfish   441 HPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVE-ACQSREELRPLGELILRPEKGIWIK 504

  Fly   507 VRER 510
            ::.|
Zfish   505 LQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	196/476 (41%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	196/476 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950