DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	538	Identity:	144/538 - (26%)
Similarity:	236/538 - (43%)	Gaps:	81/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVG------HGHHFIGKPPHEMVKKIFEFM 65
            |.||:.|.:.....|..||:|     .:|||..:|..|      .|.|.......|...:|:...
Zfish    12 AFLAALLVIYGSWPHRYFKKL-----GIPGPKAIPFFGTMLRYKDGFHVFDMDCFEKYGRIWGIY 71

  Fly    66 ETYS-----KDQ-VLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRG 124
            :...     .|| ::|..|..|...|..|.::       .|.|..          |.:.:.::..
Zfish    72 DGRQPVLCIMDQTIIKTVLIKECYSLFTNRRN-------FRLNGA----------LYDAVSIAED 119

  Fly   125 RKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICE 189
            ..|.:.|.:::|:|....|.:...:.:|.|..|:.:|.: ..|.|:|. .:.::....:||.:..
Zfish   120 DDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGK-TAKRGESA-DIKEFFGAYSMDVVTS 182

  Fly   190 TAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEK 254
            ||..|.|::.:|....:|..:|.            :.:|||   |.||.     .|.....|...
Zfish   183 TAFSVDIDSLNNPKDPFVTNIKK------------MLKFDL---LNPLF-----LLIAFFPFMAP 227

  Fly   255 IIVQRREEL------------IREGSSQESSNDDADVGAKRKMAFLDILLQSTV----------D 297
            ::.:....|            :::..|...:...|....|:::.||.:::.|..          .
Zfish   228 VLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHT 292

  Fly   298 ERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYEL 362
            |:.||:.:|..:...|:|.|::|:||.|.|.|||:||:||..||..|||.....|  ..||.||.
Zfish   293 EKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPN--QAPVDYET 355

  Fly   363 LNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIF 427
            |..:.|:|..:.|:||::|....|.|...:..||||.|||....:.:....|.|..:.:|||..|
Zfish   356 LMSMDYLDAALSESLRLFPVAARLERVCKKTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESF 420

  Fly   428 KPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLI 492
            ||||| .....|.::||.|:||..|||||||.:||.:.:|..:..:|:.::|....::..|..|.
Zfish   421 KPERF-TKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELG 484

  Fly   493 AELILRTKEPLMFKVRER 510
            ...:|..|:|:..|::.|
Zfish   485 FNGLLSPKDPIKLKLQPR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	134/505 (27%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	134/505 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910