Protein Alignment Cyp4d1 and Cyp3a41a

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_059092.2
• Gene: Cyp3a41a / 53973
• MGIID: 1858451
• Length: 504
• Species: Mus musculus
• Alignment Length: 535
• Identity: 143/535 - (26%)
• Similarity: 255/535 - (47%)
• Gaps: 82/535 - (15%)

  Fly     8 ILASALFVGLLLY----HLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEF-MET 67
            :|.:.:.|.|..|    |..||:     ..:|||..||.:|...::        .|.:::| ||.
Mouse    13 VLLAIILVLLYRYGTRTHGLFKK-----QGIPGPKPLPFLGTVLNY--------YKGLWKFDMEC 64

  Fly    68 YSK----------DQVLKVWLGPEL--NVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLL 120
            |.|          ...|.|...||:  |||:   |:...|....|.....|       .:.:.:.
Mouse    65 YEKYGKTWGLFDGQMPLFVITDPEMIKNVLV---KECFSVFTNRREFGPVG-------IMSKAIS 119

  Fly   121 VSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMD 185
            :|:..:|.:.|.:::|.|....|.:...|.|:....|::.:.|:..|  ....::.|.:...::|
Mouse   120 ISKDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEK--GKPVTMKDVLGAYSID 182

  Fly   186 TICETAMGVSINAQSNADSEYVQAVKTISMV--LHKRMFN-ILYRFDLTYMLTPLARAEKKALNV 247
            .|..|:.||::::.:|.:..:|:..|.|..|  ....:|: :|:.|     |||:    .:.||:
Mouse   183 VITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPF-----LTPV----YEMLNI 238

  Fly   248 LH------QFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILL---QSTVDE---RP 300
            ..      :|.:|.:.:.:|..:             |...|.::.||.:::   .::.|:   :.
Mouse   239 CMFPKDSIEFFKKFVNRMKESRL-------------DSKQKHRVDFLQLMMNAHNNSKDKDSHKA 290

  Fly   301 LSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQ 365
            ||:::|..:...|:|.|::||||.|.|..|.:||||:.|||..|||...:.|  ..|.:|:.:.:
Mouse   291 LSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPN--KAPPTYDTVME 353

  Fly   366 LHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPE 430
            :.|:|:.:.||||:||....|.|...:|.|:||..||.|:.:.|....|....:.:.||..|:||
Mouse   354 MEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPE 418

  Fly   431 RFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAEL 495
            ||...... .::||.|:||..|||||||.:||.:.:|..:..|::::......::..|..|..:.
Mouse   419 RFSKENKG-SIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQG 482

  Fly   496 ILRTKEPLMFKVRER 510
            :|:.::|::.||..|
Mouse   483 LLQPEKPIVLKVVPR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	121/447 (27%)
Cyp3a41a	NP_059092.2	CYP3A	67..493	CDD:410743	122/462 (26%)