DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	174/481 - (36%)
Similarity:	265/481 - (55%)	Gaps:	38/481 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVL-MGNPKDVEVVL-GTLRFNDKAG-E 107
            ||..:..|..|.:|::.|.:.||  .|....||||.:.:: :.:|..:..|| .:.....|.| .
  Rat    62 GHLGMSPPTEEGMKQMTELVATY--PQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDGIF 124

  Fly   108 YKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSG 172
            |..|:|||.:|||||...||.:.|.::||||||.||..:|::|...:.  :.:.:..||..|.|.
  Rat   125 YSFLKPWLGDGLLVSASDKWSRHRSMLTPAFHFNILKPYVKIFNDSTN--IMHAKWLRLASGGSA 187

  Fly   173 -FSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTP 236
             ..:::.|:|.|:||:.:.....:.|.|.. .|||:.|:..:|.::.||...:|...||.|.|||
  Rat   188 HLDMFENISLMTLDTLQKCVFSFNSNCQEK-PSEYIAAILELSALVVKRNEQLLLHMDLLYRLTP 251

  Fly   237 LARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRK---MAFLDILLQS-TVD 297
            ..|...||.:::|.||..:|.:||..|.:.|      .||. :.||.|   :.|:|:||.| ..|
  Rat   252 DGRRFYKACHLVHDFTYAVIQERRRTLPKHG------GDDV-IKAKAKSKTLDFIDVLLLSKDED 309

  Fly   298 ERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYEL 362
            .:.||:.|||.|.|||||||||||:|.|.:..||:|.|||.|::|.:|::.::.:..|..:....
  Rat   310 GKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDSEEIECSC 374

  Fly   363 -------LNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREE 419
                   |.||.::.:|:||:||::|.|.::.|...:|..: :|::||.|....|:.........
  Rat   375 GVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRVIPKGIICIINIFATHHNPT 439

  Fly   420 LFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGD 484
            ::.:|.::.|.||| ....:..:|.|:|||||||||||||.|||.|:|..||..|..:.|  :.|
  Rat   440 VWQDPEVYDPFRFD-PENIQARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRV--LPD 501

  Fly   485 SSEP---PVLIAELILRTKEPLMFKV 507
            ..||   |    |||||.::.|..:|
  Rat   502 DKEPRRKP----ELILRAEDGLWLRV 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	173/479 (36%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	169/466 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750