DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	204/542 - (37%)
Similarity:	307/542 - (56%)	Gaps:	47/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFM 65
            |::|:.|.||..||: :..:.|...|...:::...||.:|||||:.|. :|..|.|::.:.|.:.
  Fly     1 MWIVLCAFLALPLFL-VTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQ-MGNTPTEILNRFFGWW 63

  Fly    66 ETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKR 130
            ..|.||. .:.|:|...|:::.|||.:|.:|.:.....|:..|....|||..|||.|.|.||||.
  Fly    64 HEYGKDN-FRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKH 127

  Fly   131 RKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDW---INLCTMDTICETAM 192
            ||:|||||||.||..|.||..:.|...:     |:||....|.:::|:   .:..|:|.||:|||
  Fly   128 RKMITPAFHFNILQDFHEVMNENSTKFI-----DQLKKVADGGNIFDFQEEAHYLTLDVICDTAM 187

  Fly   193 GVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIV 257
            ||||||..|..|..|||.|.|:..:..|.|:...|....:...|......|.|..|..||.:||.
  Fly   188 GVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIA 252

  Fly   258 QRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTS 322
            :|.|  :|:...:....  ||..:::||||||.||.|.||.|||::.::.|||.||||||||||:
  Fly   253 KRIE--VRKSGLEVGIK--ADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTT 313

  Fly   323 SALMFFFYNIATHPEAQKKCFEEIRSVVG-NDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLL 386
            |.:.|..|.::.||:.|:|.|.|...|:| :......:::.::.:.::||.:||..|:|||||.:
  Fly   314 SGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFI 378

  Fly   387 GRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSA 451
            ||...:|..|:|.::|.||.:.:..|.||..:.:|.:|:.|:|||||    .||..|:.|:||||
  Fly   379 GRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFD----REKPGPFEYVPFSA 439

  Fly   452 GPRNCIGQKFAMLEIKAIVANVLRHYEV-----DFVGDSS--------EP--------------P 489
            |||||||||||:||||.:|:.::|::||     :.|....        :|              |
  Fly   440 GPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDP 504

  Fly   490 VLIAELILRTKEPLMFKVRERV 511
            :|.|.:.|:::..|..::::|:
  Fly   505 ILSASMTLKSENGLHLRMKQRL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	194/502 (39%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	187/449 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449051
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900