DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	135/523 - (25%)
Similarity:	254/523 - (48%)	Gaps:	50/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILASALFVGLL----LYHLKFKRLIDLISY-MPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67
            :|...|:.|||    :|.|..:|...|::. :|||...|::|..|..:.:  .:::.....|::.
  Fly     1 MLTWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRR--EDILNAFGCFLDK 63

  Fly    68 YSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRK 132
            :.  ..:..||||...:::.:|:.|:.:..:....:|...|||::.....||...:..:|...||
  Fly    64 HG--PTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRK 126

  Fly   133 IITPAFHFKILDQFVEVFEKGSRDLLRNME--QDRLKHGDSGFSLYDWINLCTMDTICETAMGVS 195
            ::.|||..|:|..|:.:|.:.:..||..:|  ||     |....|...:...|:....:|.||..
  Fly   127 LLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQD-----DGEKDLIPLLQSFTLGIATQTTMGSD 186

  Fly   196 INAQSNADS-----EYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEK---KALNVLHQFT 252
            :..:.:..|     .|...::|::.:......|  .||     ...||..|.   :|...:.||.
  Fly   187 VKDEESFRSNSLLGRYQCILETMTDMCFSPWLN--SRF-----CRQLAGKESHYYQAKTEIRQFI 244

  Fly   253 EKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNL-DIREEVDTFMFE 316
            .|||.::..|..........|||        |..||:::  :.:..|.:..| ::.:|.:..:|.
  Fly   245 RKIIERKLAEDEMGALPSIQSND--------KNLFLNLV--TDLMRRGVFTLKNVEDESNIIVFG 299

  Fly   317 GHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYP 381
            ..:||::|:.:....:|..||.|::.||||:::..|.....|||....|:.|:||.:.|::|:.|
  Fly   300 AFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIP 364

  Fly   382 SVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFS-EPNIFKPERFDVVTTAEKLNPY 444
            .||::.|:..:|.:: ||.::|.|..|.|...::.|.::::. :...|.|:.|......:| :||
  Fly   365 PVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDK-HPY 428

  Fly   445 AYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY--EVDFVGDSSEPPVLIAELILRTKEPLMFKV 507
            |||||:.|.|||||.::|::..|..:|.:||:|  :..|   ..|....:.::.::.|...:.::
  Fly   429 AYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSF---PFENLYFVEDITMKLKSVPLLEL 490

  Fly   508 RER 510
            ::|
  Fly   491 QKR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	125/486 (26%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	122/458 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860