DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and cyp46a1.2

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_009292815.1	Gene:	cyp46a1.2 / 393433	ZFINID:	ZDB-GENE-040426-1184	Length:	501	Species:	Danio rerio

Alignment Length:	509	Identity:	140/509 - (27%)
Similarity:	234/509 - (45%)	Gaps:	74/509 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQV 73
            |.||:|...|.|.|....|.....::||||      ..:..:|..| .:.|.:      ||.|.:
Zfish    13 LLSAVFTAFLAYCLYIHHLHQKYDHIPGPP------RDNFLLGHSP-SLTKAM------YSDDSL 64

  Fly    74 LK----VW---LGP--ELN------VLMGNPKDVEVVLGTLRFNDKAGEYKAL-----EPWLKEG 118
            :.    .|   .||  .:|      :|:..|:..:.:|.:.::......|..|     :.:|..|
Zfish    65 IHDLFLQWAEKYGPVYRINTLHYIAILVHCPEATKTILMSPKYAKDPFSYSRLFNLFGKRFLGNG 129

  Fly   119 LLVSRGRK-WHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLC 182
            |:.:.... |:::|:|:.|||....|...:..|::.|..|:..:|:  :.:..:...::|.:|..
Zfish   130 LVTAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEE--MANNKTPAVMHDLVNCV 192

  Fly   183 TMDTICETAMGVSINAQSNADSEYVQAVKTI--SMVLHKRMFNILYRFDLTYMLTPLARAEKKAL 245
            |:|.||:.|.||.:|..:..||.:..|::..  .|.|..|              .||.|...|..
Zfish   193 TLDVICKVAFGVDLNFLTQKDSPFQNAIELCLNGMALDAR--------------DPLFRIFPKNW 243

  Fly   246 NVLHQFTEKIIVQRR--EELIREGSSQESSNDDA--DVGAKRKMAFLDILLQSTVDERPLSNLDI 306
            .::.|..:..::.|:  |:.|:...:...:.:|.  |:        |..:|:...:|...|:.|:
Zfish   244 KLIQQIRDAAVLLRKTGEKWIQNRKTAVKNGEDVPKDI--------LTQILKIAEEENVNSSEDL 300

  Fly   307 REEVD---TFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHY 368
            .:.:|   ||...|.:||::.|.|....:..:||..|:...|:..|:|..:.  :|.|.|.:|.|
Zfish   301 EQMMDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKRE--ISNEDLGKLTY 363

  Fly   369 VDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFD 433
            :...:|||||:||:.|...|.:.||..|||..||.|.::..|.....|.|:.|.:|..|.|||||
Zfish   364 LSQVLKETLRLYPTAPGTNRWLHEDMIINGIKIPGGCSVMFSSFVSQRLEKFFKDPLKFDPERFD 428

  Fly   434 VVTTAEKLNP-YAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSS 486
              ..|.|  | |.|.||:.|||.|:||.|:.:|.|.::|.:|:.:|...|...|
Zfish   429 --ENAPK--PYYCYYPFALGPRTCLGQVFSQMEAKVVLAKLLQRFEFSLVPGQS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	132/483 (27%)
cyp46a1.2	XP_009292815.1	p450	39..495	CDD:278495	132/483 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910