DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	505	Identity:	174/505 - (34%)
Similarity:	282/505 - (55%)	Gaps:	29/505 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFVGLLLYHLKF----KRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQV 73
            :|:..||..:|.    ::.:..:...||||...|.||...| .:..|:: :||.::||.|  ...
Zfish    20 IFLACLLTVVKLLIVRRKGVKTMERFPGPPAHWLFGHVKEF-RQDGHDL-EKIVKWMELY--QFA 80

  Fly    74 LKVWLGPELNVL-MGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPA 137
            ..:|.||.|.|| :.:|..|:.:|.|....|... ||...|||.:|||||.|:||.:.|:::||.
Zfish    81 FPLWFGPSLAVLNIHHPSYVKTILTTTEPKDDYA-YKFFIPWLGDGLLVSTGQKWFRHRRLLTPG 144

  Fly   138 FHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNA 202
            ||:.:|..:|::....::.:|...|..  ...:..|.|:..::|.|:|:|.:.|...:.|.|:::
Zfish   145 FHYDVLKPYVKLISDSTKVMLDKWEVH--SRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDS 207

  Fly   203 DSE-YVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIRE 266
            .:. |:|||..:..:::.|.....|.....:.|:|.....:||.::.|..|.::|.:|:|.|..|
Zfish   208 GTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKME 272

  Fly   267 GSSQESSNDDADVGAKRKMAFLDILLQSTVDE--RPLSNLDIREEVDTFMFEGHDTTSSALMFFF 329
                   .:...|..:|.:.|||||| |..||  :.||:.|||.|||||||||||||:|.:.:.|
Zfish   273 -------EEQGIVKNRRYLDFLDILL-SARDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIF 329

  Fly   330 YNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDC 394
            ||:|.:||.|:||.:||:..:  |....:.:|.||::.|..:|:||:||::|.||.:.||:.:..
Zfish   330 YNLACNPEHQEKCRQEIQQAL--DGKATLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPL 392

  Fly   395 E-INGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIG 458
            . .:|:.:|.|..||:|...:.....::..|..|.|.||.....|.: :|:|::|||||||||||
Zfish   393 TFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENVANR-SPHAFVPFSAGPRNCIG 456

  Fly   459 QKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVR 508
            |.|||.|:|..||..|:.|.:  :.|....|.:|.:::||:...:..|::
Zfish   457 QNFAMNEMKVAVALTLKRYYL--IKDPDHTPKMIPQVVLRSLNGIHIKIK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	169/476 (36%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	169/474 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750