DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	202/519 - (38%)
Similarity:	308/519 - (59%)	Gaps:	28/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVIGAILASALFVGLLLYHLKFKRLIDLI---SYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEF 64
            |:.||::.      ||.:....||...|.   |.:|||..:|::|.|...:......::..:.|.
  Fly     5 LITGALIL------LLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEK 63

  Fly    65 METYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHK 129
            .:.|.|  ..:.|:..|..:...:.:..|.:|.:....:|...|:.|.|:|.:|||||.|||||.
  Fly    64 FDKYGK--TFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGRKWHA 126

  Fly   130 RRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGV 194
            ||||.|.|||||:|:.:||:.::.|..::.|:.  ::..|.:...:..:::|..:|.|.|.||||
  Fly   127 RRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLR--KVADGKTAVDMLKYVSLAALDVITEAAMGV 189

  Fly   195 SINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLA-----RAEKKALNVLHQFTEK 254
            .:|||::.|..|::|:|::..:...|||....|::   .|.|||     |.....:.|:|.||:|
  Fly   190 QVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYN---WLFPLAAPLLHRQLLSDIRVMHDFTDK 251

  Fly   255 IIVQRREELIR---EGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFE 316
            :|.:|||.:.|   :|:.:..|..||::|:|.:||.|||||||:::.:|||:.||||||||||||
  Fly   252 VISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFE 316

  Fly   317 GHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYP 381
            |.|||||.:....|.||.|||.|::.|||::.|:|.|.|.||:...|..|.|:|..:|||:|:||
  Fly   317 GDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYP 381

  Fly   382 SVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAY 446
            .||.:||...::.||..|.|||.|:|.:...|..|....|.:|..|:|||| :....:..|.:||
  Fly   382 PVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERF-LEDQEQGHNTFAY 445

  Fly   447 IPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRER 510
            :||||||:||||||||:||:|.:::.|||.||:..:|:..:|   :...|||:...:...:|.|
  Fly   446 VPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKP---MLNFILRSASGINVGLRPR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	191/479 (40%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	188/469 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449052
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910