DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp6a2

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	136/562 - (24%)
Similarity:	238/562 - (42%)	Gaps:	107/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFLVIGAILA-SALFVGLLLYHLKFKRLIDLISY-----MPGPPVLPLVGH---------GHHFI 50
            ||::|..::| |:|..  .|||..|       :|     :|.....||.|:         .|.|.
  Fly     1 MFVLIYLLIAISSLLA--YLYHRNF-------NYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFF 56

  Fly    51 GKPPHEMVKKIFEFMETYSKDQVLKVWLGPEL--NVLMGNPKDVEVVLGTLRFNDKAGEYKALEP 113
            ....::..|..|.|:..|...:.....:..:|  |:|:   ||..      .|.|:...:...:.
  Fly    57 YDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILI---KDFS------NFADRGQFHNGRDD 112

  Fly   114 WLKEGLLVSRGRKWHKRRKIITPAFH-----------FKILDQFVEVFEKGSRDLLRNMEQDRLK 167
            .|.:.|....|:||...|:.:||.|.           .|:.::||:|.          .||....
  Fly   113 PLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVI----------TEQVPAA 167

  Fly   168 HGDSGFSLYDWINLCTMDTICETAMGVSINAQSNADSEY-VQAVKTISMVLHKRMFNILYRFDLT 231
            ...:...:.:.:...|.|.|...|.|:..|......|:: ....|..:.:.|.::.. ::.|...
  Fly   168 QNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLT-MFVFSFP 231

  Fly   232 YMLTPLARAEKKALNVLHQF-----TEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDIL 291
            .:.:.| |......:| |||     .:.|.::.||...|        ||           |:::|
  Fly   232 KLASRL-RMRMMPEDV-HQFFMRLVNDTIALRERENFKR--------ND-----------FMNLL 275

  Fly   292 LQ------STVDE-RPLSNLDIRE---EVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEI 346
            ::      .|:|. ..:..:||.|   :|..|...|.:|:||.:.:..|.:|.:.:.|.:...||
  Fly   276 IELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEI 340

  Fly   347 RSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGK---LIPAGTNIG 408
            ::|: .::...::||.:..:.|::..:.||||:|..||.|.||.|.|..:.|.   :|..||.:.
  Fly   341 QTVL-EEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVI 404

  Fly   409 ISPLYLGRREELFSEPNIFKPERF--DVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVA 471
            |......|.|:|:..|..|.||||  :.|...|.:.   ::||..|||||||.:|..::.:..:|
  Fly   405 IPACAYHRDEDLYPNPETFDPERFSPEKVAARESVE---WLPFGDGPRNCIGMRFGQMQARIGLA 466

  Fly   472 NVLRHYEVDFVGDSSEPPVLIA--ELILRTKEPLMFKVRERV 511
            .::..:.|. |.|::|.|:..:  .::|.|...:..:| ||:
  Fly   467 QIISRFRVS-VCDTTEIPLKYSPMSIVLGTVGGIYLRV-ERI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	122/516 (24%)
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	121/511 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910