DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	201/508 - (39%)
Similarity:	304/508 - (59%)	Gaps:	28/508 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AILASALFVGLLLY---HLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETY 68
            |::|..|:...|.|   .|.|.||......:|||.:..|:.:    :.|  .|::..:.|..|.:
  Fly     5 ALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIAN----VKK--GEILNWLKELREKH 63

  Fly    69 SKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKI 133
            .  .|.::|.|.:|.|:..:|:|::.:||..:...|:..|:.|||||.:|||.:.|..||:|||:
  Fly    64 G--PVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKL 126

  Fly   134 ITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINA 198
            :||.|||:||.:|.|..|:..|.|:|.:   |.|.....|.:|.:|.|..:|.|||||||:..:|
  Fly   127 LTPGFHFRILSEFKEPMEENCRILVRRL---RTKANGESFDIYPYITLFALDAICETAMGIKKHA 188

  Fly   199 QSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREEL 263
            |..:||||||||::|..|:||:.|:...|.::.:..|...:..:.||.|||..|.::|..|||:|
  Fly   189 QLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQL 253

  Fly   264 IREGSSQESSNDDADVGAKRKMAFLDILLQSTVD-ERPLSNLDIREEVDTFMFEGHDTTSSALMF 327
            |:|.:..:...:..||||||::||||:||.:.:: ...||:.||||||||||||||||||||:.|
  Fly   254 IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAF 318

  Fly   328 FFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLE 392
            ....::.:|:.|::.|||...:.|.:|.:         :.|::..:|||||:|||||...|||||
  Fly   319 ALSLLSKNPDVQQRAFEEASELEGREKES---------MPYLEAVIKETLRIYPSVPFFSRKVLE 374

  Fly   393 DCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCI 457
            |.|:....:|.|.:|......|.|..:.|.:|..|.|:||  :...::::|:|:..|||||||||
  Fly   375 DLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF--LVNEKQMHPFAFAAFSAGPRNCI 437

  Fly   458 GQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRER 510
            ||||||||:|..:|.:||.|.  |:.|....|..:|||:.::...:..::..|
  Fly   438 GQKFAMLELKTSLAMLLRSYR--FLPDKDHQPKPLAELVTKSGNGIRLRILPR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	191/472 (40%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	188/457 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460455
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910