DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	527	Identity:	143/527 - (27%)
Similarity:	243/527 - (46%)	Gaps:	81/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLY----HLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVW 77
            ||:|    |..||:|     .:|||..||.||....:        .|.|..|....|| :..|||
Zfish    21 LLIYGVWPHGFFKKL-----GIPGPRPLPFVGTALSY--------SKGICNFDIECSK-KYGKVW 71

  Fly    78 --LGPELNVLMGNPKDVEVVLGTL------RFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKII 134
              ....|.:|:  ..|:|::...|      .|.::......|.....:|:.:.:..:|.:.|..:
Zfish    72 GIYDGRLPLLL--VTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKDERWRRIRSSL 134

  Fly   135 TPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQ 199
            :|.|....|.:...:....:...::|||:   |..:....:.|.:...::|.:..::..|..::.
Zfish   135 SPYFTSGRLKEIFPIAMTHADRFIKNMEK---KDPNLPLKIKDVVAPYSLDVVASSSFSVDFDSI 196

  Fly   200 SNADSEYVQAVKTISMVLHKRMFNI--LYRFDLTYMLTPLAR--AEKKALNVLHQFTEKIIVQRR 260
            :|.|..:|.::|:        .|||  |....|.....|.|.  ..|..::|..:.|.....:..
Zfish   197 NNPDDPFVTSIKS--------FFNINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTTDFYYKAL 253

  Fly   261 EELIREGSSQESSNDDADVGAKRKMAFLDILLQS---------TVDERPLSNL---DIREEVDTF 313
            .::..|   ...||...|        ||.:::|:         |..|:|:..|   :|..:...|
Zfish   254 RKIKDE---HNESNGRVD--------FLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFIF 307

  Fly   314 MFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKS----TPVSYELLNQLHYVDLCVK 374
            :..|::|||:.|.:..||:||:|:..:|..|||      ||:    .|::|:.|.::.|:::.:.
Zfish   308 ILGGYETTSTTLSYLLYNLATNPDCLEKLVEEI------DKNFPLDIPITYDALMRMDYLEMAIH 366

  Fly   375 ETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLY-LGRREELFSEPNIFKPERFDVVTTA 438
            |::|::|:.|.|.|...:..||||..||..|.:|| ||| |.|..:|:..||.||||||...:..
Zfish   367 ESMRVFPAGPRLERVCKKTVEINGITIPKNTLVGI-PLYVLSRDPDLWESPNEFKPERFSPESKT 430

  Fly   439 EKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPL 503
            | :|..|::||..|||||||.:||::.:|.:|..:|:.|.|:...::..|..|  ....:.|.|:
Zfish   431 E-INQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQL--NFFFQPKVPI 492

  Fly   504 MFKVRER 510
            ..|:..|
Zfish   493 TLKLIPR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	134/500 (27%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	134/500 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910