DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	199/519 - (38%)
Similarity:	298/519 - (57%)	Gaps:	40/519 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILASALFVGLL---LYHLKFKRL-IDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETY 68
            :|..||.|..|   |:.|..|.| ..|...:|....:||:|.........|..:..|..|:::.:
  Fly     4 VLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAEYVKRF 68

  Fly    69 SKDQVLKVWLGPEL-NVLM--GNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKR 130
            .:.     ::|..| :|:|  ..|:.::.:|.......|...|.||..||.:|||:|||::||..
  Fly    69 GRS-----FMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHTM 128

  Fly   131 RKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVS 195
            ||||||.|||.||:||||||::.|..|:..:.  .|.:|:...::|..:.|..:|.|.||||||:
  Fly   129 RKIITPTFHFSILEQFVEVFDRQSSILVERLR--TLSYGNEVVNIYPLVGLAALDIITETAMGVN 191

  Fly   196 INAQSNADSEYVQAVKTISMVLHKR------MFNILYRFDLTYMLTPLA-RAEKKALNVLHQFTE 253
            ::|| .||||.|.|||.::.:|..|      :|..|:|     :..|.. |.::..:..||:||.
  Fly   192 VDAQ-GADSEVVHAVKDLTNILATRFMRPHLLFPHLFR-----LCWPSGFRKQQAGVICLHEFTN 250

  Fly   254 KIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGH 318
            .||.|||..|.||.:..:.:         :..|.||.||::|||.:||::..||:||:||:||||
  Fly   251 GIIEQRRRLLAREANQDKPT---------KPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGH 306

  Fly   319 DTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSV 383
            |||:||:.|..|.::.|...|:|.|||:|...|.|....|.......|.|:...|||:||:||.:
  Fly   307 DTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPI 371

  Fly   384 PLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIP 448
            |.:.|.:.:|..|:...||.|||:.:....|.|.|.:|::|.:|:||| .:...|.:|:||:|||
  Fly   372 PAVARCLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPER-HLGEEAPRLSPYSYIP 435

  Fly   449 FSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRERVY 512
            ||||||||||||||:||:|.:|..|:|||::..:|...||.:   :::||:|..:...:|.|:|
  Fly   436 FSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSI---KIVLRSKSGVNVGLRPRLY 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	186/481 (39%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	186/476 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449044
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910