DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and cyp19a1a

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_571229.3	Gene:	cyp19a1a / 30390	ZFINID:	ZDB-GENE-990415-43	Length:	517	Species:	Danio rerio

Alignment Length:	545	Identity:	126/545 - (23%)
Similarity:	216/545 - (39%)	Gaps:	128/545 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ASALFVGLLL-------YHLKFKRLIDLISYMPGPPVLPLVGHGHHFIG-KPPHEMVKKIFEFME 66
            |:|..:.|||       :|...|      |::|||         ..|.| .|.....:.|:..:.
Zfish    42 ATATILLLLLCLLLAIRHHRPHK------SHIPGP---------SFFFGLGPVVSYCRFIWSGIG 91

  Fly    67 TYSK------DQVLKVWLGPELNVLMGNPKDVEVVLG----TLRFNDKAGEYKALE--PWLKEGL 119
            |.|.      ..:::||:..|..:::.....|..||.    |.||..|.|    |:  ...::|:
Zfish    92 TASNYYNSKYGDIVRVWINGEETLILSRSSAVYHVLRKSLYTSRFGSKLG----LQCIGMHEQGI 152

  Fly   120 LV-SRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCT 183
            :. |....|.|.|.....|.....|.:.:|:....:...|.::.|  |........:.:.:....
Zfish   153 IFNSNVALWKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQ--LTDAQGQLDILNLLRCIV 215

  Fly   184 MDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFN----ILYRFDLTYMLTPLARAEKKA 244
            :|......:||.:|     :.:.:|.:       || .|:    :|.:.|:.:.|..|.:..|:.
Zfish   216 VDVSNRLFLGVPLN-----EHDLLQKI-------HK-YFDTWQTVLIKPDVYFRLDWLHKKHKRD 267

  Fly   245 LNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLD-----ILLQSTVDERPLSNL 304
            ...|......:|.|::.:|..                ..|:..||     |..||   ...||..
Zfish   268 AQELQDAITALIEQKKVQLAH----------------AEKLDHLDFTAELIFAQS---HGELSAE 313

  Fly   305 DIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYV 369
            ::|:.|...:....||.|.:|.|....:..:|:.:.|..:|:.||:....   :.:..|::|..:
Zfish   314 NVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVLAGQS---LQHSHLSKLQIL 375

  Fly   370 DLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGR--REELFSEPNIFK---- 428
            :..:.|:||.:|.|....|:.|:|..|.|..:..||||   .|.:||  |.|.||:||.|.
Zfish   376 ESFINESLRFHPVVDFTMRRALDDDVIEGYNVKKGTNI---ILNVGRMHRSEFFSKPNQFSLDNF 437

  Fly   429 ----PERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYE--------VDF 481
                |.||             :.||.:|||:|:|:..||:.:|:|:..:|..:.        |:.
Zfish   438 HKNVPSRF-------------FQPFGSGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACTVEN 489

  Fly   482 VGDSS--------EPPVLIAELILR 498
            :..::        ||..|..:||||
Zfish   490 IPQTNNLSQQPVEEPSSLSVQLILR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	118/513 (23%)
cyp19a1a	NP_571229.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589892
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950