DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	179/535 - (33%)
Similarity:	292/535 - (54%)	Gaps:	63/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VIGAILASALFVGLLLYHL---KFKRLIDL------ISYMPGPPVLP-LVGHGHHFIGKPPHEM- 57
            |:.|:|   ||:..||:.|   .||...|.      :|..|.||... |:||...::   |:|.
  Rat    23 VLSALL---LFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPGRHWLLGHMSMYL---PNEKG 81

  Fly    58 ---VKKIFEFMETYSKDQVLKVWLGPELNVL-MGNPKDVEVVLGTLRFNDKAGE--YKALEPWLK 116
               .||:.:.|.     .::..|:||.|.:| :.:|..::.|||.........|  |..|:|||.
  Rat    82 LQNEKKVLDTMH-----HIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLG 141

  Fly   117 EGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGD-SGFSLYDWIN 180
            :|||:|:|.||.:.|:::||||||.||..::::|.: |.:::....:..|..|. :.|.:::.::
  Rat   142 DGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQ-SVNIMHAKWRRHLAEGSVTSFDMFEHVS 205

  Fly   181 LCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKAL 245
            |.|:|::.:.....|.:.|... |:|:.::..:|.::.:|.:.:.:..|..|.||...|..::|.
  Rat   206 LMTLDSLQKCVFSYSSDCQEKL-SDYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQAC 269

  Fly   246 NVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAK--RKMAFLDILLQSTVDE-RPLSNLDIR 307
            :.:|.||.::|.|||..|...|:       :|.:.||  :.:.|:|:||.:..:| :.||:.|||
  Rat   270 DTVHNFTTEVIQQRRRALRELGA-------EAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIR 327

  Fly   308 EEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLC 372
            .|.|||||||||||||.|.:..:|:|.:||.|.||.|||:.|:...:...:.::.|.||.:..:|
  Rat   328 AEADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMC 392

  Fly   373 VKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGIS-------PLYLGRREELFSEPNIFKP 429
            :||:||.:|.|.|:.|:..||.:: :|::||.|....:|       ||       ::.:..::.|
  Rat   393 IKESLRQFPPVTLISRRCTEDIKLPDGRIIPKGIICLVSIYGTHYNPL-------VWPDSKVYNP 450

  Fly   430 ERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY--EVDFVGDSSEPPVLI 492
            .||| ....::.:|.|::||||||||||||.|||.|::.:||..|..:  .||........|
  Rat   451 YRFD-PDIPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRKP--- 511

  Fly   493 AELILRTKEPLMFKV 507
             ||||||:..|...|
  Rat   512 -ELILRTENGLWLNV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	166/493 (34%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	158/466 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750