DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	170/522 - (32%)
Similarity:	286/522 - (54%)	Gaps:	51/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GAILASALFVGL---LLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67
            ||.|.| ||:.|   :.::|:.:.|:..:...|..|       .|...|   |::..:.|:.:.|
  Rat    21 GAFLLS-LFLVLFKAVQFYLRRQWLLKALEKFPSTP-------SHWLWG---HDLKDREFQQVLT 74

  Fly    68 YSKDQVLKV------WL-GPELNVLMGNPKDVEVVLGTLRFNDKA-GEYKALEPWLKE----GLL 120
            :    |.|.      || |.:..||:.:|..|:||||  |.:.|| |.|:.|.||:..    |||
  Rat    75 W----VEKFPGACLQWLSGSKTRVLLYDPDYVKVVLG--RSDPKASGIYQFLAPWIVSGTGYGLL 133

  Fly   121 VSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMD 185
            :..|:||.:..:::|||||:.||..:|::.......:|...|  :|...|....::.:::|.|:|
  Rat   134 LLNGKKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWE--KLDDQDHPLEIFHYVSLMTLD 196

  Fly   186 TICETAMGVSINAQSNADS-EYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLH 249
            |:.:.|.....:.|.:.:| .|.:||:.::.:...|:.:..|...:.|.::...|..::|..:.|
  Rat   197 TVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAH 261

  Fly   250 QFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTV-DERPLSNLDIREEVDTF 313
            :.|:.:|..|:.:|..|...|::..       ||.:.||||||.:.: |.:.||:.|:|.|||||
  Rat   262 EHTDGVIKMRKAQLQNEEELQKARK-------KRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTF 319

  Fly   314 MFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLR 378
            ||||||||:|.:.:.||.:|||||.|::|.||::|::|:  .|.|:::.|:|:.|..:|:||.||
  Rat   320 MFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGD--GTSVTWDHLDQISYTTMCIKEALR 382

  Fly   379 MYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLN 442
            :||.||.:.|::...... :|:.||.|....|....|......:..|.:|.|.||   :.....:
  Rat   383 LYPPVPSVSRELSSPVTFPDGRSIPKGITTTILIYGLHHNPSYWPNPKVFDPSRF---SPDSPRH 444

  Fly   443 PYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKV 507
            .:||:|||.|.|||||::|||.|:|..||..|..:|:  :.|.:..||.:|.|:|::|..:..::
  Rat   445 SHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL--LPDPTRIPVPMARLVLKSKNGIHLRL 507

  Fly   508 RE 509
            ::
  Rat   508 KK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	161/486 (33%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	156/458 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850