DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	174/541 - (32%)
Similarity:	279/541 - (51%)	Gaps:	81/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIG-----KPPHEMVKKIF 62
            |::||  ||.:...:|.:...|......:...|..|      ..:.|:|     :...|.::.:.
  Rat    22 LLLGA--ASWILARILAWTYSFCENCSRLRCFPQSP------KRNWFLGHLGTIQSNEEGMRLVT 78

  Fly    63 EFMETYSKDQVLKVWLGPELNVL----------------MGNPKDVEVVLGTLRFNDKAGEYKAL 111
            |..:|:.  .:...||||.:.||                :..|||...    |||         |
  Rat    79 EMGQTFR--DIHLCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTF----LRF---------L 128

  Fly   112 EPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKH----GDSG 172
            :|||.:||.:|.|.||.:.|:::||||||.||..:|::|.:..     |:...:.||    |.:.
  Rat   129 KPWLGDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSV-----NIMHAKWKHLCLEGSAR 188

  Fly   173 FSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPL 237
            ..:::.|:|.|:|::.:...|...|.| .:.|||:.|:..:|.::.||...:....|..|..|..
  Rat   189 LEMFENISLMTLDSLQKCLFGFDSNCQ-ESPSEYISAILELSSLIIKRSQQLFLYLDFLYYRTAD 252

  Fly   238 ARAEKKALNVLHQFTEKIIVQRREELIREGSSQ--ESSNDDADVGAKRKMAFLDILLQSTVDE-- 298
            .|..:||.:::|.||:.:|.:||..|..:|:.:  ||...    ...:.:.|:|:||.:. ||
  Rat   253 GRRFRKACDLVHNFTDAVIRERRRLLSSQGTDEFLESKTK----SKSKTLDFIDVLLLAK-DEHG 312

  Fly   299 RPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELL 363
            :.||:.|||.|.|||||.|||||:|||.:..||:|.|||.|::|.:|:..::.:.:...:.::.|
  Rat   313 KELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDL 377

  Fly   364 NQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIF 427
            .||.::.:|:||:||::|....|.|:..:|..: :|::||.|....||...:.....::.:|.:|
  Rat   378 AQLPFLTMCIKESLRLHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVF 442

  Fly   428 KPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEP---P 489
            .|.||| ....:|.:|.::|||||||||||||.|||.|:|.:||..|..:.|  :.|..||   |
  Rat   443 DPFRFD-SENRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRFRV--LPDDKEPRRKP 504

  Fly   490 VLIAELILRTK-------EPL 503
                |:|||.:       |||
  Rat   505 ----EIILRAEGGLWLRMEPL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	167/509 (33%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	164/502 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348550
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740