DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	178/523 - (34%)
Similarity:	281/523 - (53%)	Gaps:	46/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67
            |::|.  ||.:...:|.:...|......:...|.|| .|....||..:.|...|.::.|......
  Rat    23 LLLGG--ASWILARILAWIYTFYDNCCRLRCFPQPP-KPSWFWGHLTLMKNNEEGMQFIAHLGRN 84

  Fly    68 YSKDQVLKVWLGPELNVL-MGNPKDVEVVLG----------TLRFNDKAGEYKALEPWLKEGLLV 121
            : :|..|. |:||...:| :.:|..:..:|.          ||        |..|:|||.:|||:
  Rat    85 F-RDIHLS-WVGPVYPILRLVHPNVIAPLLQASAAVAPKEMTL--------YGFLKPWLGDGLLM 139

  Fly   122 SRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDT 186
            |.|.||:..|:::||||||.||..:|::|.|....:....::...| |.:...:::.|:|.|:|:
  Rat   140 SAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAK-GSARLDMFEHISLMTLDS 203

  Fly   187 ICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQF 251
            :.:.......|.| .::|||:.|:..:|.::.||........|..|.||...|..:||.:|:|.|
  Rat   204 LQKCIFSFDSNCQ-ESNSEYIAAILELSSLIVKRQRQPFLYLDFLYYLTADGRRFRKACDVVHNF 267

  Fly   252 TEKIIVQRREELIREGSSQESSNDDADVGAKRK-MAFLDILLQSTVDE--RPLSNLDIREEVDTF 313
            |:.:|.:||..|..:|     .::.....||.| :.|:|:||.:. ||  :.||::|||.|.|||
  Rat   268 TDAVIRERRSTLNTQG-----VDEFLKARAKTKTLDFIDVLLLAK-DEHGKGLSDVDIRAEADTF 326

  Fly   314 MFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLR 378
            ||.|||||:|||.:..||:|.|||.|::|.:|:|.::.:.:...:.::.|.||.::.:|:||:||
  Rat   327 MFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLR 391

  Fly   379 MYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLN 442
            ::|.|.|:.|...:|..: :|::||.|....||...:.....::.:|.::.|.||| ....:|.:
  Rat   392 LHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFD-PENPQKRS 455

  Fly   443 PYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEP---PVLIAELILRTKEPLM 504
            |.|:|||||||||||||.|||.|||..:|..|..:.|  :.|..||   |    |||||.:..|.
  Rat   456 PLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCV--LPDDKEPRRKP----ELILRAEGGLW 514

  Fly   505 FKV 507
            .:|
  Rat   515 LRV 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	171/489 (35%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	171/487 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750