DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	161/519 - (31%)
Similarity:	283/519 - (54%)	Gaps:	38/519 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VIGAI-LASALFVGLLL-----YHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIF 62
            ::|.: :|:.|.|.|||     ::|..:.|:......|.||       .|.|.|.....:|.:.|
  Rat    15 ILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPP-------SHWFFGHKLSFLVDQEF 72

  Fly    63 EFMETYSKD--QVLKVWL-GPELNVLMGNPKDVEVVLGTLRFNDKA-GEYKALEPWLKEGLLVSR 123
            :.:.|..|:  .....|| |..:.:.:.:|..::::||  |.:.|: ..|:.|.||:..|||:..
  Rat    73 QDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILG--RSDPKSHHSYRFLAPWIGYGLLLLN 135

  Fly   124 GRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTIC 188
            |:.|.:.|:::|||||:..|..:|.:.....|.:|...||  :...||...::..|.|.|:|||.
  Rat   136 GQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQ--IVGQDSTLEIFQHITLMTLDTIM 198

  Fly   189 ETAMGVSINAQSNAD-SEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFT 252
            :.|.....:.|.:.. ..|::||:.::.:...|:.||.::.|:.|.|:...|..:.|..:.|:.|
  Rat   199 KCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 263

  Fly   253 EKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDE-RPLSNLDIREEVDTFMFE 316
            :::|..|:.:|..|...|:       |..||::.||||||.:.::. ..||:.|:|.||||||||
  Rat   264 DQVIKSRKAQLQDEEELQK-------VKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFE 321

  Fly   317 GHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYP 381
            |||||:|.:.:.||.:||:||.|:.|.:||:|::|:..|  ::::.|:::.|..:|:||.||:||
  Rat   322 GHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGAS--ITWDDLDKMPYTTMCIKEALRIYP 384

  Fly   382 SVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYA 445
            .|..:.|.:...... :|:.:|.|..:.:|...|.....::..|.:|.|.||   ......:.::
  Rat   385 PVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRF---APESSRHSHS 446

  Fly   446 YIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRE 509
            ::|||.|.|||||::|||.|:|..||..|..:|:  :.|.:..|:.|..|:|::|..:..::::
  Rat   447 FLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL--LPDPTRIPIPIPRLVLKSKNGIYLRLKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	152/478 (32%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	145/450 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750