DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	165/524 - (31%)
Similarity:	268/524 - (51%)	Gaps:	73/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67
            :||..::...|| .|||...|..|.:|   ..||||...|.||.               .|..:.
  Rat    19 VVILMVIVLKLF-SLLLRRQKLARAMD---SFPGPPTHWLFGHA---------------LEIQKL 64

  Fly    68 YSKDQVLK----------VWLGPELNVL-------------MGNPKDVEVVLGTLRFNDKAGEYK 109
            .|.|:|:.          :|.|..:..|             .|:||..:|             |.
  Rat    65 GSLDKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAADV-------------YD 116

  Fly   110 ALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFS 174
            ....|:.:||||..|.||.:.||::||.||:.:|..:|.:|.:.:|.:|...|:...:  :..|.
  Rat   117 FFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASE--NKSFD 179

  Fly   175 LYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLAR 239
            ::..:....:||:.:...|...:...:.|:.|..||..:::::.:|:.:..|..|..|.|||..|
  Rat   180 IFCDVGHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGR 244

  Fly   240 AEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDER--PLS 302
            ...:|..:.|..|:::|.||:..|       :...:...:..:|.:.|||||| ...||.  .||
  Rat   245 RFLRACKIAHDHTDEVIRQRKAAL-------QDEKERKKIQQRRHLDFLDILL-GVRDESGIKLS 301

  Fly   303 NLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLH 367
            :.::|.|||||||||||||:|.:.:|.|.:|.:||.|:.|.||:|.::|:..|  ..::.|.::.
  Rat   302 DAELRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDS--FQWDDLAKMT 364

  Fly   368 YVDLCVKETLRMYPSVPLLGRKVLEDCE-INGKLIPAGTNIGISPLYLGRREELFSEPNIFKPER 431
            |:.:|:||..|:||.||.:.|::.:... ::|:.:|||:.|.:....|.|...::.:|.:|.|.|
  Rat   365 YLTMCMKECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLR 429

  Fly   432 FDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELI 496
            |.....|.: :|:|::||||||||||||:|||.|:|.:.|..|..:|  |..|.|:.|:.:.:||
  Rat   430 FSPENAAGR-HPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFE--FSLDPSKMPIKVPQLI 491

  Fly   497 LRTK 500
            ||:|
  Rat   492 LRSK 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	155/492 (32%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	155/492 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750