DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	527	Identity:	176/527 - (33%)
Similarity:	280/527 - (53%)	Gaps:	61/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILASALFVGLLL-----YHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPH-EMVKKIFEFME 66
            ::.::||:..:|     ::..:.||    ...|.||      ..|.|.|   | .|||...|.::
Mouse    24 LVGASLFLARILTWICAFYDNYCRL----RCFPEPP------SRHWFWG---HMSMVKNNEEGLQ 75

  Fly    67 -----TYSKDQVLKVWLGPELNVL-MGNPKDVEVVLGTLRFNDKAGE---------YKALEPWLK 116
                 ::....|...|:||...:| :.:||.:..:|       :|..         |..|:|||.
Mouse    76 LLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGPIL-------QASAAVAPKEMIFYGFLKPWLG 133

  Fly   117 EGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINL 181
            :|||||.|.||.:.|.::||||||.||..:::.|.| |.:::....|.....|.:...:.:.|:|
Mouse   134 DGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNK-SVNIMHAKWQRLTTKGTACLDMLEHISL 197

  Fly   182 CTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALN 246
            .|:|::.........|.| .:.|||:.|::.:|.::.||........|..|..|...|..:||.:
Mouse   198 MTLDSLQNCVFSFDSNCQ-ESPSEYIAAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACD 261

  Fly   247 VLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRK---MAFLDILLQSTVDE--RPLSNLDI 306
            ::|.||:.:|.:||..|       .|.|.|..:.:|.|   :.|:|:||.:. ||  :.||:.||
Mouse   262 LVHNFTDAVIRERRRTL-------SSQNLDEFLKSKTKSKTLDFIDVLLLAK-DEHGKELSDEDI 318

  Fly   307 REEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDL 371
            |.|.|||||.|||||:|||.:..||:|.|||.|::|.:|::.::...:...:.::.|.||.::.:
Mouse   319 RAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEWDDLAQLPFLTM 383

  Fly   372 CVKETLRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVV 435
            |:||:||::|.|.::.|...:|..: :|::||.||:..||...:....|::.:|.::.|.||| .
Mouse   384 CIKESLRLHPPVTVISRCCTQDVVLPDGRVIPKGTDCVISIFGVHHNPEVWPDPEVYDPFRFD-P 447

  Fly   436 TTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTK 500
            ...:|.:|.|:|||||||||||||.|||.|:|..:|..|..:.| ..||  :.|....|||||.:
Mouse   448 ENPQKRSPLAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRV-LPGD--KEPRRKPELILRAE 509

  Fly   501 EPLMFKV 507
            ..|..:|
Mouse   510 GGLWLRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	170/493 (34%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	170/492 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750