Protein Alignment Cyp4d1 and cyp-13A12

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_499705.1
• Gene: cyp-13A12 / 184473
• WormBaseID: WBGene00008810
• Length: 518
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 148/583 - (25%)
• Similarity: 243/583 - (41%)
• Gaps: 159/583 - (27%)

  Fly     1 MFLVIGAILASALFVGLLLYHL----KFKRLIDLISYMPGPPVLPLVGHGHHFIG--KPPHEMVK 59
            |.::..|||.|  .:|:|.::|    .:||     ..:.||...|::|.....:.  .||:..:|
 Worm     1 MAIIFLAILTS--IIGVLSFYLWTWSYWKR-----RGIAGPSGYPILGSALEMLSSENPPYLQLK 58

  Fly    60 -------KIFEFMETYSK-------DQVLKVWL-------GPELNVLMGNP-KDVEVVLGTLRFN 102
                   |::...|..|:       |.|.:|::       |.:||.:.|:| ||..|
 Worm    59 EWTKQYGKVYGITEGLSRTLVISDPDLVQEVFVKQYDNFFGRKLNPIQGDPNKDKRV-------- 115

  Fly   103 DKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLK 167
                           .|..|:|.:|.:.|.|.:|.|....|.:.....|:.:.:|||::||
 Worm   116 ---------------NLFSSQGHRWKRLRTISSPTFSNNSLRKLKTTVEECAVELLRHIEQ---- 161

  Fly   168 HGDSG--FSLYDWINLCTMDTICETAMGVSINAQSNADSE--------YVQAV------------ 210
            |.|.|  ..|.|:....|:|.|...|||       ..||:        ||:||
 Worm   162 HTDGGQPIDLLDFYQEFTLDVIGRIAMG-------QTDSQMFKNPLLPYVRAVFGEPRKGLFLSG 219

  Fly   211 ---KTISMVLHKRMF---NILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSS 269
               ..|..:|...||   ||:               :..|::|:...:.  .|::|.:|
 Worm   220 SLAPWIGPILRMVMFSLPNIV---------------KNPAVHVIRHTSN--AVEQRVKL------ 261

  Fly   270 QESSNDDADVGAKRKMAFLDILLQSTVDERPLSN--------LDIREEVDT---------FMFEG 317
             ..:::.|.:.......|:|:.|.:..|:..|.|        :.:..::.|         |:..|
 Worm   262 -RMADEKAGIDPGEPQDFIDLFLDAKSDDVELENNEDFTKAGVKVTRQLTTEEIVGQCFVFLIAG 325

  Fly   318 HDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPS 382
            .|||:.:|.:..:.:||||:.|||..|||.....:.:   |:::.|::|.|::..:||||||||
 Worm   326 FDTTALSLSYSSFLLATHPKVQKKLQEEIDRECADPE---VTFDQLSKLKYMECVIKETLRMYP- 386

  Fly   383 VPLLGRKVLEDC-----EINGKLIPAGTNIGISPLYLGRREELFSE-PNIFKPERFDVVTTAEK- 440
               ||......|     :|....|..||||......|...:.::.| ...|||||::   :.::
 Worm   387 ---LGALANSRCCMRATKIGNYEIDEGTNILCDTWTLHSDKSIWGEDAEEFKPERWE---SGDEH 445

  Fly   441 -LNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEP 502
             .....||||..|||.|||.:.|.:|.|.:::::||.|.::....:..|..||..   ||.:|
 Worm   446 FYQKGGYIPFGLGPRQCIGMRLAYMEEKLLLSHILRKYTLEVCNKTQIPLKLIGS---RTTQP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	127/491 (26%)
cyp-13A12	NP_499705.1	CYP3A-like	63..507	CDD:410678	131/514 (25%)