Protein Alignment Cyp4d1 and cyp-25A1

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_497775.3
• Gene: cyp-25A1 / 183247
• WormBaseID: WBGene00007963
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 551
• Identity: 142/551 - (25%)
• Similarity: 242/551 - (43%)
• Gaps: 96/551 - (17%)

  Fly     3 LVIGAILAS--ALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIG--KPPHEMVKKI-- 61
            |::.:::.|  ..|:.::|...:..:|.:.|. :.||       ..|.|:|  |...|..:|:
 Worm     4 LILSSLVISIFTFFIYIILARRERFKLREKIG-LSGP-------EPHWFLGNLKQTAERKEKLGY 60

  Fly    62 -------FEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVL--GTLRFNDKA--GEYKALEPWL 115
                   .|..|.|.  :...::.|.::|:::.|.||::.|.  ....|:|::  ..|:|.:  |
 Worm    61 DDANRWFNELHEQYG--ETFGIYYGSQMNIVISNEKDIKEVFIKNFSNFSDRSVPSIYEANQ--L 121

  Fly   116 KEGLLV-SRGRKWHKRRKIITPAF---HFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLY 176
            ...||: |....|...|..|.|.|   ..|.:.:.:    ....||..::.:::...|.. :.:|
 Worm   122 TASLLMNSYSSGWKHTRSAIAPIFSTGKMKAMQETI----NSKVDLFLDILREKASSGQK-WDIY 181

  Fly   177 DWINLCTMDTICETAMGVSINAQSNA-DSEYVQAVKTISM--VLHKRM-------------FNIL 225
            |.....|:|.|.:.|..:..|.|.:. |..||.|.|.||.  :.|.::             :..|
 Worm   182 DDFQGLTLDVIGKCAFAIDSNCQRDRNDVFYVNAKKYISNIDIRHSKIIAASVLLPELSTFWKAL 246

  Fly   226 YRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDI 290
            |::      ||||.||...:..|....|:          |.|.....|.|           .|.:
 Worm   247 YKY------TPLADAEIPLVEGLSNVYER----------RRGGEGSDSVD-----------LLKL 284

  Fly   291 LLQSTVDE-RPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDK 354
            ||....|: :|::..::.|....|:..|::|||:|:.:..|.::.:|..|:|.:|||.....|..
 Worm   285 LLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEAKENGG 349

  Fly   355 STPVSYELLNQLHYVDLCVKETLRMYPSV-PLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRRE 418
            .|   |:.::.:.|:|...|||||.||.| ..:.|...||..|.|:..|.|..:...|..:.|..
 Worm   350 LT---YDSIHNMKYLDCVYKETLRFYPPVIHFIRRLCREDITIRGQFYPKGAIVVCLPHTVHRNP 411

  Fly   419 ELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEV-DFV 482
            |.:..|..|.||||:  ...||.:...:|||..|||.|:|.:||.:|.|..:..:|..:|: .|.
 Worm   412 ENWDSPEEFHPERFE--NWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIVKLLDTFELKQFE 474

  Fly   483 GDSSEPPVLIAE---LILRTKEPLMFKVRER 510
            |::.    ||.:   :|:|..:|:...::.|
 Worm   475 GEAD----LIPDCNGVIMRPNDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	124/460 (27%)
cyp-25A1	NP_497775.3	CYP3A-like	73..495	CDD:410678	125/466 (27%)