DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	525	Identity:	180/525 - (34%)
Similarity:	278/525 - (52%)	Gaps:	51/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMET 67
            |::|.  ||.:...:|.:...|......:...|.|| .|....||..:.|...|.:    :|:..
Mouse    22 LLLGG--ASWILARILAWIYAFYDNCSRLRCFPQPP-KPSWFWGHLALMKNNEESM----QFITH 79

  Fly    68 YSKD--QVLKVWLGPELNVL-MGNPKDVEVVLG----------TLRFNDKAGEYKALEPWLKEGL 119
            ...|  .|...|:||...:| :.:|..:..:|.          ||        |..|:|||.:||
Mouse    80 LGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTL--------YGFLKPWLGDGL 136

  Fly   120 LVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTM 184
            |:|.|.||...|:::||||||.||..:|::|.| |.:::....|.....|.|...:::.|:|.|:
Mouse   137 LMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNK-SVNIMHAKWQCLASKGTSRLDMFEHISLMTL 200

  Fly   185 DTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLH 249
            |::.:....|..|.| .:||:|:.|:..:|.::.||........||.|.||...|..:||.:::|
Mouse   201 DSLQKCIFSVDSNCQ-ESDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVH 264

  Fly   250 QFTEKIIVQRREELIREGSSQESSNDDADVGAKRK-MAFLDILLQSTVDE--RPLSNLDIREEVD 311
            .||:.:|.:||..|..:|.      :.....||.| :.|:|:||.:. ||  :.|||.|||.|.|
Mouse   265 NFTDAVIKERRSTLNTQGV------EFLKAKAKTKTLDFIDVLLMAE-DEHGKGLSNEDIRAEAD 322

  Fly   312 TFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKET 376
            ||||.|||||:|||.:..||:|.|||.|::|.:|::.::.:..|..:.::.|.||.::.:|:||:
Mouse   323 TFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLTMCIKES 387

  Fly   377 LRMYPSVPLLGRKVLEDCEI-NGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEK 440
            ||::|.|.|:.|...:|..: :|:.||.|....||...:.....::.:|.::.|.||| ....:|
Mouse   388 LRLHPPVLLISRCCTQDVLLPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFD-PENPQK 451

  Fly   441 LNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEP---PVLIAELILRTKEP 502
            .:|.|:||||||.||||||.|||.|||..:|..|..:.:  :.|..||   |    |||||.:..
Mouse   452 RSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRI--LPDDKEPRRKP----ELILRAEGG 510

  Fly   503 LMFKV 507
            |..:|
Mouse   511 LWLRV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	173/491 (35%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	173/489 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750