Protein Alignment Cyp4d1 and Cyp3a62

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_001019403.1
• Gene: Cyp3a62 / 170509
• RGDID: 1595919
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 148/529 - (27%)
• Similarity: 263/529 - (49%)
• Gaps: 71/529 - (13%)

  Fly     8 ILASALFVGLLLY----HLKFKRLIDLISYMPGPPVLPLVG------HGHHFIGKPPHEMVKKIF 62
            :|.:.:.|.|.||    |..||:|     .:.||..||.||      ||.....:..|:....|:
  Rat    13 MLLATILVLLYLYGTSTHGNFKKL-----GISGPKPLPFVGNILAYRHGFWEFDRHCHKKYGDIW 72

  Fly    63 EFMETYSKDQVLKVWLGPEL--NVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGR 125
            .|.|  .:..:|.: ..|::  .||:   |:........|....||       .||:.:.:|...
  Rat    73 GFYE--GRQPILAI-TDPDIIKTVLV---KECYSTFTNRRSFGPAG-------ILKKAITLSEDE 124

  Fly   126 KWHKRRKIITPAF-------HFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCT 183
            :|.:.|.:::|.|       .|.|::|:.::       |::|::.:..|  .:..::.|.....:
  Rat   125 EWKRLRTLLSPTFTSGKLKEMFPIINQYADL-------LVKNVKHEAEK--GNPITMKDIFGAYS 180

  Fly   184 MDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVL 248
            ||.|..|:.||::::.:|..:.:||.||.:      ..||.|..|.|:.:|.|......:|.::.
  Rat   181 MDVITGTSFGVNVDSLNNPQNPFVQKVKKL------LKFNFLDPFFLSVILFPFLTPVFEAFDIT 239

  Fly   249 HQFTEKII--VQRREELIREGSSQESSNDDADVGAKRKMAFLDILL--QSTVDE---RPLSNLDI 306
             .|.:.::  .:...|.::|...||.        .|:::.||.:::  ||:.|:   :.|::::|
  Rat   240 -VFPKDVMKFFRTSVERMKENRMQEK--------VKQRLDFLQLMINSQSSGDKESHQGLTDVEI 295

  Fly   307 REEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDL 371
            ..:...|:|.|::||||||.|..|.:||||:.|||..:||.:.:.|  ..||:|::|.::.|:|:
  Rat   296 VAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAALPN--KAPVTYDVLVEMEYLDM 358

  Fly   372 CVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVT 436
            .:.||||::|....|.|...:|.||||..||.||.:.:....|.:..:.:.||..|.||||. ..
  Rat   359 VLNETLRLFPVGGRLERVCKKDVEINGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFR-KK 422

  Fly   437 TAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKE 501
            ..:.:|||.|:||..|||||||.:||::.:|..:..||:::......::..|..|..:...:.::
  Rat   423 NQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEK 487

  Fly   502 PLMFKVRER 510
            |::.:...|
  Rat   488 PIILRAVSR 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	126/446 (28%)
Cyp3a62	NP_001019403.1	CYP3A	67..492	CDD:410743	129/464 (28%)