Protein Alignment Cyp4d1 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 131/531 - (24%)
• Similarity: 216/531 - (40%)
• Gaps: 107/531 - (20%)

  Fly     7 AILASAL--FVGLLLYHLKFKRLIDL-----------ISYMPGPPVLPLVG-------------- 44
            |:|||||  ||..||..|...:|.||           :...||....|..|
Human     5 ALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQ 69

  Fly    45 ---------HGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLR 100
                     :..|..|:|.          :.....|.|.::.||....|.:..|..|..:||:
Human    70 MKRRKYGFIYKTHLFGRPT----------VRVMGADNVRRILLGEHRLVSVHWPASVRTILGS-- 122

  Fly   101 FNDKAGEYKALEPWLKEGLLVSRGRKWHK-RRKIITPAFHFKILDQFVEVF--EKGSRDLLRNME 162
                             |.|.:.....|| |:|:|..||..:.|:.:|.|.  |.||     ::|
Human   123 -----------------GCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGS-----SLE 165

  Fly   163 QDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYR 227
            | .|..|:.|..:|..:............:|.......:.|||. |.|:..     :.|...|:.
Human   166 Q-WLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQ-QLVEAF-----EEMTRNLFS 223

  Fly   228 FDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREEL--IREGSSQESSNDDADVGAKRKMAFLDI 290
            ..:....:.|.|. .||.|::|...|:.|   |.::  :|...:.:...|           .|.:
Human   224 LPIDVPFSGLYRG-MKARNLIHARIEQNI---RAKICGLRASEAGQGCKD-----------ALQL 273

  Fly   291 LLQSTVD--ERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRS---VV 350
            |::.:.:  || |....:::.....:|.||:||:||.......:..:|...:|..||::|   :.
Human   274 LIEHSWERGER-LDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLC 337

  Fly   351 GNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLG 415
            .:::...:..|:|.||.|:...:|||||:.|.||...|..|:..|:||..||.|.|:..|.....
Human   338 KSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTH 402

  Fly   416 RREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVD 480
            ...|:|:....|.|:|| ::...|..:.:::|||..|.|:|:|::||.:.:|.....:.||.:..
Human   403 DVAEIFTNKEEFNPDRF-MLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQ 466

  Fly   481 FVGDSSEPPVL 491
            .:   :.||.:
Human   467 LL---NGPPTM 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	109/429 (25%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	114/481 (24%)