Protein Alignment Cyp4d1 and CYP24A1

DIOPT Version :10

• Sequence 1: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Sequence 2: NP_000773.2
• Gene: CYP24A1 / 1591
• HGNCID: 2602
• Length: 514
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 134/505 - (26%)
• Similarity: 237/505 - (46%)
• Gaps: 84/505 - (16%)

  Fly    34 MPGPPVLPLVGHGHHFIG----KPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEV 94
            :|||...||:|.....:.    |..|:   .:.|:.:.|.|  :.::.||...:|.:|:|..:|.
Human    58 LPGPTSWPLLGSLLQILWKGGLKKQHD---TLVEYHKKYGK--IFRMKLGSFESVHLGSPCLLEA 117

  Fly    95 VLGT-----LRFNDKAGEYKALEPWLKE--GLLVSRGRKWHK-----RRKIITPAFHFKILDQFV 147
            :..|     .|...|  .:||...:.||  |||:..|..|.:     ::|::.|....|:.::..
Human   118 LYRTESAYPQRLEIK--PWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

  Fly   148 EVFEKGSRDLLRNMEQ--DRLKHGDSGFSLYDWINLCTMDTIC----ETAMGVSINAQSNADSE- 205
            ||.    .|.:..:::  |...|.:   .||..:|..:.::||    |...|:   .|.||..|
Human   181 EVL----ADFMGRIDELCDERGHVE---DLYSELNKWSFESICLVLYEKRFGL---LQKNAGDEA 235

  Fly   206 --YVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVL----HQFTEKIIVQRREELI 264
              ::.|:||: |....||           |:||:..  .|:||..    |......|.:..:..|
Human   236 VNFIMAIKTM-MSTFGRM-----------MVTPVEL--HKSLNTKVWQDHTLAWDTIFKSVKACI 286

  Fly   265 REGSSQESSNDDADVGAKRKMAFL-DILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFF 328
            .....:.|....||        || ||..|:.     ||..::...|........:||:::||:.
Human   287 DNRLEKYSQQPSAD--------FLCDIYHQNR-----LSKKELYAAVTELQLAAVETTANSLMWI 338

  Fly   329 FYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLED 393
            .||::.:|:.|:|..:||:||: .:...|.:.:|.| :.|:..|:||::|:.||||...| .|:.
Human   339 LYNLSRNPQVQQKLLKEIQSVL-PENQVPRAEDLRN-MPYLKACLKESMRLTPSVPFTTR-TLDK 400

  Fly   394 CEINGK-LIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCI 457
            ..:.|: .:|.||.:.::...||..|:.|.:.:.|:|||:  :...||:||:|::||..|.|.||
Human   401 ATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERW--LQEKEKINPFAHLPFGVGKRMCI 463

  Fly   458 GQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLI--AELILRTKEPLMF 505
            |::.|.|::...:..::|.|::.  ...:||..::  ..|:...:.|:.|
Human   464 GRRLAELQLHLALCWIVRKYDIQ--ATDNEPVEMLHSGTLVPSRELPIAF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	CYP4	73..504	CDD:410721	122/459 (27%)
CYP24A1	NP_000773.2	CYP24A1	90..508	CDD:410738	123/465 (26%)