DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d1 and CYP19A1

DIOPT Version :9

Sequence 1:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens

Alignment Length:	521	Identity:	127/521 - (24%)
Similarity:	221/521 - (42%)	Gaps:	87/521 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AILASALFVGLLLYHLKFKRLIDLISYMPGP----PVLPLVGHGHHF---IGKPPHEMVKKIFEF 64
            |.:...|..||.|....::.    .|.:|||    .:.||:.||...   ||...:...:...||
Human    24 ATMPVLLLTGLFLLVWNYEG----TSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEF 84

  Fly    65 METYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALE--PWLKEGLLVSRGRK- 126
            |         :||:..|..:::.....:..::....::.:.|....|:  ...::|::.:...:
Human    85 M---------RVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPEL 140

  Fly   127 WHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKH--GDSGF----SLYDWINLCTMD 185
            |...|.....|.....|.:.|.|..:..:..|     |||:.  .:||:    :|...:.|.|.:
Human   141 WKTTRPFFMKALSGPGLVRMVTVCAESLKTHL-----DRLEEVTNESGYVDVLTLLRRVMLDTSN 200

  Fly   186 TIC------ETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKA 244
            |:.      |:|:.|.|..       |..|.:.           :|.:.|:.:.::.|.:..:|:
Human   201 TLFLRIPLDESAIVVKIQG-------YFDAWQA-----------LLIKPDIFFKISWLYKKYEKS 247

  Fly   245 LNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREE 309
            :..|....|.:|.::|..:    |::|...:..|...:.      ||.:...|   |:..::.:.
Human   248 VKDLKDAIEVLIAEKRRRI----STEEKLEECMDFATEL------ILAEKRGD---LTRENVNQC 299

  Fly   310 VDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVK 374
            :...:....||.|.:|.|..:.||.||..::...:||::|:|   ...:..:.:.:|..::..:.
Human   300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG---ERDIKIDDIQKLKVMENFIY 361

  Fly   375 ETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGR--REELFSEPNIFKPERFDVVTT 437
            |::|..|.|.|:.||.|||..|:|..:..||||   .|.:||  |.|.|.:||.|..|.|
Human   362 ESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI---ILNIGRMHRLEFFPKPNEFTLENF----- 418

  Fly   438 AEKLNPYAYI-PFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFV-GDSSEPPVLIAELILRTK 500
             .|..||.|. ||..|||.|.|:..||:.:|||:..:||.:.|..: |...|....|.:|.|...
Human   419 -AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPD 482

  Fly   501 E 501
            |
Human   483 E 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	121/493 (25%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	112/469 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950